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Genomics of Endemic Burkitt Lymphoma

ABSTRACT:

This genomic landscape of Burkitt lymphoma represents a multimodal sequencing of tumors and control tissues and individuals to better understand the etiology, and molecular pathogenesis of Burkitt lymphoma including the roles of the associated Plasmodium falciparum malaria and EBV infections. Comprehensive sequencing set includes genomic, transcriptomic, and epigenomic datasets in concert with variable clinical phenotypes and outcome information such as anatomical presentation site, in-hospital survival rates, and EBV genome type. The initial deposit represents polyA RNA-seq from tumor specimens from 28 cases of endemic BL and 2 cases of sporadic BL.

For initial transcriptome analysis see: Kaymaz et al. Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type-specific Difference. Molecular Cancer Research: MCR, January. doi:10.1158/1541-7786.MCR-16-0305.
For general overview of cohort study see: Buckle et al. Factors influencing survival among Kenyan children diagnosed with endemic Burkitt lymphoma between 2003 and 2011: A historical cohort study. Int J Cancer. 15:1231, 2016.

PROVIDER: phs001282 | dbGaP |

SECONDARY ACCESSION(S): PRJNA369585PRJNA369584

REPOSITORIES: dbGaP

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