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Genomic Analysis of Pre-Treatment and Autopsy Glioblastoma Specimens

ABSTRACT:

We performed whole exome sequencing data of pre-treatment glioblastoma specimens, matched to post-treatment recurrent intracranial autopsy samples and metastatic extracranial post-treatment autopsy samples. We identified early genetic events common to the evolutionary ancestry of both pre-treatment glioblastoma and later recurrences. We demonstrated that there were no protein-coding mutations as recurrent truncal events across the majority of the cohort. In contrast, we identified four truncal non-coding genomic alterations that likely represent the precursor cell population of glioblastoma.

PROVIDER: phs001424 | dbGaP |

SECONDARY ACCESSION(S): PRJNA397304PRJNA397303

REPOSITORIES: dbGaP

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