Genomics

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Sequencing of Brain Tissue in Mental Disorders and Non-psychiatric Individuals Whole Genome Sequencing


ABSTRACT: All brains were collected and dissected at the HBCC, DIRP, NIMH. This study generates whole genome sequencing data using sequencing of DNA in the dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC) or cerebellum of 443 individuals with schizophrenia, bipolar disorder and major depressive disorder and non-psychiatric controls. For subject and brain collection description, see Parent Study Summary (dbGaP accession: phs001567phs001567. All specimens were dissected from right or left hemisphere of frozen coronal slabs. DNA Library Preparation and Sequencing: All samples submitted to the New York Genome Center for WGS were prepared for sequencing in randomized batches of 95. The sequencing libraries were prepared using the Illumina PCR-free DNA sample preparation Kit. The insert size and DNA concentration of the sequencing library was determined on Fragment Analyzer Automated CE System (Advanced Analytical) and Quant-iT PicoGreen (ThermoFisher... (for more see dbGaP study page.)

PROVIDER: phs001574 | dbGaP |

REPOSITORIES: dbGaP

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