Genomics

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A single cell transcriptomic analysis of human neocortical development


ABSTRACT: Defining the number, proportion, or lineage of distinct cell types in the developing human brain is an important goal of modern brain research. We produced single cell transcriptomic profiles for 40,000 cells at mid-gestation to define deep expression profiles corresponding to all known major cell types at this developmental period and compare this with bulk tissue profiles. We identified multiple transcription factors (TFs) and co-factors expressed in specific cell types, including multiple new cell-type-specific relationships, providing an unprecedented resource for understanding human neocortical development and evolution. This includes the first single-cell characterization of human subplate neurons and subtypes of developing glutamatergic and GABAergic neurons. We also used these data to deconvolute single cell regulatory networks that connect regulatory elements and transcriptional drivers to single cell gene expression programs in the developing... (for more see dbGaP study page.)

ORGANISM(S): Homo sapiens  

PROVIDER: phs001836 | dbGaP |

REPOSITORIES: dbGaP

Dataset's files

Source:
Action DRS
GapExchange_phs001836.v1.p1.xml Xml
dbGaPEx2.1.5.xsd Other
Study_Report.phs001836.NeocorticalDevelopment.v1.p1.MULTI.pdf Pdf
manifest_phs001836.NeocorticalDevelopment.v1.p1.c1.GRU.pdf Pdf
datadict_v2.xsl Other
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| phs001205 | dbGaP