Genomics

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High dimensional analyses of CD4+ T cells in human lymph nodes


ABSTRACT: The High dimensional analyses of CD4+ T cells in human lymph nodes is a case-based analysis of the TCR repertoire, transcriptome, and epigenetic signatures of various CD4+ T cells in human lymph nodes. The study aims to determine clonal overlap between phenotypically distinct CD4+ T cells and the similarities between these populations on transcriptional and epigenetic levels. This study performs TCR repertoire sequencing using Molecular Identifier Clustering-based Immune Repertoire Sequencing (MIDCIRS). We found clonal overlap between a population of CXCR5- T cells and Tfh cells. We also show epigenetic and transcriptional similarities between CXCR5-PD-1+ T cells and Tfh cells.

PROVIDER: phs001849 | dbGaP |

REPOSITORIES: dbGaP

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