Genomics

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Invariant patterns of clonal succession determine specific clinical features of Myelodysplastic syndromes (MDS)


ABSTRACT: Myelodysplastic Syndromes (MDS) are heterogeneous myeloid neoplasms, characterized by stepwise acquisitions of multiple somatic mutations. Mutational configurations (e.g. bi-allelic) and specific distributions, timing of acquisitions corresponding to rank within the clonal hierarchy, and combinatorial spectrum are not elucidated. Therefore, we conducted targeted deep sequencing in a panel of the 36 most frequently mutated "myeloid" genes in terms of 500 patients with MDS or related myeloid neoplasms.

PROVIDER: phs001898 | dbGaP |

REPOSITORIES: dbGaP

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