Browse
Submit Data
Databases
API
Help

Dataset Information

4 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of Esketamine on Preventing Depression After Resection of the Colorectal Cancer: A Randomized Clinical Trial

ABSTRACT: Interventions: experimental group :Eesketamine + Sufentanil PCIA group (Group E, n=60, esketamine 1.0 mg / kg and sufentanil 2.0 µ g / kg);control group:Sufentanil PCIA group (Group C, n=60, sufentanil 2.0 µ g / kg) Primary outcome(s): HAMD grade;VAS grade;Postoperative adverse effects;Brain-derived neurotrophic factor(BDNF) Study Design: Parallel

DISEASE(S): Postoperative Depression

PROVIDER: 106072 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Effects of esketamine on postoperative acute pain and cognitive function in patients with gastric colorectal tumors: a randomized controlled study

Project description:Interventions: Experimental group:esketamine;Control group:sufentanil Primary outcome(s): Postoperative pain score;patient controlled intravenous analgesia (PCIA) press number;Postoperative recovery quality assessment scale of 15 items Study Design: Parallel

| 80327 | ecrin-mdr-crc

Effects of dexmedetomidine combined with epidural anesthesia on intestinal function and postoperative outcomes of patients undergoing laparoscopic colorectal cancer surgery

Project description:Interventions: Control group (CON group):Intravenous and inhalation combined anesthesia, equal amount of normal saline; Sufentanil PCIA.;Dexmedetomidine group (DEX group):Dexmedetomidine group (DEX group): intravenous anesthesia was assisted by intravenous of DEX with the loading dose of 0.5~1.0 microgram/kg completed within 10 minutes and maintenance infusion of 0.5~1.0 microgram /kg/h until the end of the operation. Sufentanil + DEX to implement PCIA.; Epidural group (EP group):Intravenous Inhalation Combined with epidural anesthesia, ropivacaine + sufentanil PCEA;DEX + EP group:Intravenous anesthesia assisted by intravenous DEX combined with epidural anesthesia, ropivacaine + DEX PCEA. Primary outcome(s): Peristalsis time after operation;Oral feeding time after operation Study Design: Parallel

| 47743 | ecrin-mdr-crc

Study on postoperative analgesia effect of lidocaine patient-controlled intravenous analgesia in patients undergoing laparoscopic colorectal tumor surgery

Project description:Interventions: Experimental group :PCIA: lidocaine 72mg/kg and normal saline are made into 300lm.;Control group:PCIA: sufentanil 2µg/kg and normal saline are made into 300lm. Primary outcome(s): Analgesic effect Study Design: Parallel

| 84982 | ecrin-mdr-crc

Effect of esketamine and sufentanil on postoperative gastrointestinal function recovery in patients undergoing laparoscopic radical resection of colorectal cancer

Project description:Interventions: The experimental group:esketamine;The control group:sufentanil Primary outcome(s): Time of first postoperative anal exhaust Study Design: Parallel

| 80915 | ecrin-mdr-crc

Effects of atomized Esketamine combined with dexmedetomidine on postoperative pharyngalgia and perioperative stress response in patients with colorectal cancer

Project description:Interventions: Blank control group:Preoperative atomization of 5ml normal saline;Esketamine group:Preoperative atomization inhalation of 0.5mg/kg Esketamine plus normal saline to prepare 5ml;Dexmedetomidine group:Atomized inhalation of 1 ug/kg dexmedetomidine plus physiological saline is 5 ml;Dexmedetomidine combined with esketamine group:Atomized inhalation of 0.25mg/kg esketamine +0.5ug/kg dexmedetomidine plus normal saline was configured as 5ml 30min before surgery Primary outcome(s): Incidence of postoperative sore throat Study Design: Parallel

| 88491 | ecrin-mdr-crc

Characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis

Project description:Ginseng (Panax ginseng Meyer) is commonly used as an herbal remedy worldwide. Few studies have explored the possible physiological changes in the liver although patients often self-medicate with ginseng preparations, which may lead to exceeding the recommended dose for long-term administration. Here, we analyzed changes in the hepatic proteins of mouse livers using quantitative proteomics after sub-chronic administration of Korean red ginseng (KRG) extract (control group and 0.5, 1.0, and 2.0 g/kg KRG) using tandem mass tag (TMT) 6‐plex technology. The 1.0 and 2.0 g/kg KRG groups exhibited signs of liver injury, including increased levels of aspartate transaminase (AST) and alanine aminotransferase (ALT) in the serum. Furthermore, serum glucose levels were significantly higher following KRG administration compared with the control group. Based on the upregulated proteins found in the proteomic analysis, we found that increased cystathionin beta-synthase (CBS) and cystathionine gamma-lyase (CSE) levels promoted greater hydrogen sulfide (HRR2RRS) synthesis in the liver. This investigation provides novel evidence that14T sub-chronic administration of 4T14TKRG can elevate HRR2RRS production by increasing protein expression of CBS and CSE in the liver.

2021-09-10 | PXD023731 | Pride

Effect of perioperative dexmedetomidine on postoperative sleep quality and rehabilitation of patients undergoing laparoscopic radical gastrectomy for gastric cancer and colorectal cancer

Project description:Interventions: Group C:Normal saline was used during operation and sufentanil was used in PCIA after operation;Group D1:Dexmedetomidine was used during operation and sufentanil was used in PCIA after operation;Group D2:Dexmedetomidine was used during operation, and sufentanil combined with dexmedetomidine was used in PCIA after operation Primary outcome(s): The sleep quality of patients;Night Sleep;The first occurrence time of bowel sounds;Intraperative drug consumption and hemodynamics;The delirium score of patients;Postoperative pain score and PCIA compression times;adverse reaction Study Design: Parallel

| 2761814 | ecrin-mdr-crc

The effect of sub-anaesthetic dose of esketamine on postoperative fatigue of in patients after laparoscopic radical resection of colorectal cancer

Project description:Interventions: group K:a bolus injection of 0.1 mg/kg esketamine intravenously after anesthesia induction, followed by a continuous intravenous infusion of 0.1 mg/kg/h throughout the operation;group C:a bolus injection of 0.1 mg/kg normal saline intravenously after anesthesia induction, followed by a continuous intravenous infusion of 0.1 mg/kg/h throughout the operation Primary outcome(s): identity consequence fatigue scale Study Design: Parallel

| 36609 | ecrin-mdr-crc

Mouse brain microarray, Chronic HDAC inhibitor treatment

Project description:Here, we examined mouse brain trancriptional changes 1 hour after the 10th daily i.p. treament with one of the four following treaments: i) vehicle control (45% saline, 45% PEG-400 and 10% DMSO administered at 7.5mL/kg), ii) Cpd-60, 45mg/kg , administered at 7.5mL/kg or iii) SAHA, 25mg/kg, administered at 5mL/kg) or iv) CI-994, 10mg/kg, administered at 5mL/kg. Cpd-60 is a benzamide HDAC inhibitor with selectivity for class I HDAC subtypes HDAC1 and HDAC2; CI-994 is a benzamide inhibitor with selectivity for HDACs1,2 and 3; SAHA is a hydroxamic acid HDAC inhibitor with selectivity for class I HDAC subtypes 1,2, and 3 and the class II HDAC subtype HDAC 6. We examined transcript differences using the Illumnia WG-6 2.0 whole genome expression array and profiled 3 specific brain regions (prefrontal cortex, nucleus accumbens, hippocampus) from each of 36 mice (n=6 mice / treatment group) . For application to array chips, we pooled two biological replicates from like treatment and brain region-groups such that 36 samples were applied in total: 4 treatment groups x 3 brain regions per treament group x 3 pools of two samples each for each treatment/brain region.

2013-05-29 | GSE47452 | GEO

Effects of different doses of dexmedetomidine on postoperative analgesia, sleep and gastrointestinal function in patients with colorectal cancer

Project description:Interventions: DEX 1 group:DEX 200 ug uesd for PCIA;DEX 2 group:DEX 400 ug used for PCIA;DEX 0 group:DEX 0 ug/kg/h uesd for PCIA Primary outcome(s): gastrointestinal function recovery;sleep disorder Study Design: Dose comparison

| 2693064 | ecrin-mdr-crc

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data