Low-Dose Total Body Irradiation and Donor Peripheral Blood Stem Cell Transplant Followed by Donor Lymphocyte Infusion in Treating Patients With Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, or Multiple Myeloma

ABSTRACT: This pilot clinical trial studies low-dose total body irradiation and donor peripheral blood stem cell transplant followed by donor lymphocyte infusion in treatment patients with non-Hodgkin lymphoma, chronic lymphocytic leukemia, or multiple myeloma. Giving total-body irradiation before a donor peripheral blood stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. When healthy stem cells from a donor are infused into the patient they may help the patient’s bone marrow make stem cells, red blood cells, white blood cells, and platelets. Once the donated stem cells begin working, the patient’s immune system may see the remaining cancer cells as not belonging in the patient’s body and destroy them. Giving an infusion of the donor’s white blood cells (donor lymphocyte infusion) may boost this effect.

DISEASE(S): Extranodal Marginal Zone B-cell Lymphoma Of Mucosa-associated Lymphoid Tissue,Lymphoma, Large B-cell, Diffuse,Lymphoma, Large-cell, Immunoblastic,Small Intestine Lymphoma,Recurrent Grade 1 Follicular Lymphoma,Refractory Hairy Cell Leukemia,Sezary Syndrome,Adult Nasal Type Extranodal Nk/t-cell Lymphoma,Splenic Marginal Zone Lymphoma,Leukemia, Hairy Cell,Refractory Chronic Lymphocytic Leukemia,Mycosis Fungoides,Lymphoma, Mantle-cell,Leukemia-lymphoma, Adult T-cell,Recurrent Adult Immunoblastic Large Cell Lymphoma,Recurrent Adult Burkitt Lymphoma,Multiple Myeloma,Leukemia, T-cell,Lymphomatoid Granulomatosis,Lymphoma, T-cell, Peripheral,Lymphoma, Extranodal Nk-t-cell,Plasmablastic Lymphoma,Lymphoma, B-cell, Marginal Zone,Burkitt Lymphoma,Recurrent Adult Diffuse Small Cleaved Cell Lymphoma,Nodal Marginal Zone B-cell Lymphoma,Recurrent Small Lymphocytic Lymphoma,Lymphoma, T-cell, Cutaneous,Recurrent Marginal Zone Lymphoma,Recurrent Adult Grade Iii Lymphomatoid Granulomatosis,Lymphoma, Follicular,Waldenstrom Macroglobulinemia,Leukemia, Lymphocytic, Chronic, B-cell,Intraocular Lymphoma,Neoplasms, Plasma Cell,Recurrent Mantle Cell Lymphoma,Recurrent Adult Acute Lymphoblastic Leukemia,Recurrent Grade 3 Follicular Lymphoma,Leukemia,Mycoses,Waldenström Macroglobulinemia,Angioimmunoblastic T-cell Lymphoma,Noncutaneous Extranodal Lymphoma,Recurrent Adult Lymphoblastic Lymphoma,Stage Ii Multiple Myeloma,Testicular Lymphoma,Lymphoma, Large-cell, Anaplastic,Lymphoma, T-cell,Hepatosplenic T-cell Lymphoma,Leukemia, Lymphoid,Immunoblastic Lymphadenopathy,Precursor Cell Lymphoblastic Leukemia-lymphoma,Stage Iii Multiple Myeloma,Recurrent Cutaneous T-cell Non-hodgkin Lymphoma,Refractory Multiple Myeloma,Lymphoma,Recurrent Mycosis Fungoides/sezary Syndrome,Anaplastic Large Cell Lymphoma,Recurrent Adult Diffuse Mixed Cell Lymphoma,Recurrent Grade 2 Follicular Lymphoma,Peripheral T-cell Lymphoma,Recurrent Adult T-cell Leukemia/lymphoma,Lymphoma, Non-hodgkin,Recurrent Adult Diffuse Large Cell Lymphoma,Lymphoma, B-cell,Cutaneous B-cell Non-hodgkin Lymphoma

PROVIDER: 2002764 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR