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Immunotherapy in Treating Patients With Resected Liver Metastases From Colon Cancer

ABSTRACT: RATIONALE: Immunotherapy using CEA-treated white blood cells may help a person’s body build an immune response to kill their tumor cells. PURPOSE: Phase I/II trial to study the effectiveness of immunotherapy with CEA-treated white blood cells in treating patients with resected liver metastases from colon cancer.

DISEASE(S): Neoplasm Metastasis,Colorectal Cancer,Metastatic Cancer

PROVIDER: 2002963 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Vaccine Therapy in Treating Patients With Advanced or Metastatic Cancer

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Vaccine Therapy and Biological Therapy in Treating Patients With Advanced Cancer

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Denileukin Diftitox Followed by Vaccine Therapy in Treating Patients With Metastatic Cancer

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Ago iCLIP of TLE patient resected hippocampus

Project description:Nine patients with temporal lobe epilepsy (TLE) underwent hippocampal resection. Six had hippocampal sclerosis, three did not show signs of hippocampal sclerosis. Resected hippocampi were used for Ago iCLIP to detect miRNA targeting in the resected tissue.

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mRNA sequencing of primary tumors resected from mice

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Vaccine Therapy in Treating Patients With Liver or Lung Metastases From Colorectal Cancer

Project description:RATIONALE: Vaccines made from a gene-modified virus and a person’s white blood cells may make the body build an effective immune response to kill tumor cells. Biological therapies, such as Granulocyte-macrophage colony-stimulating factor (GM-CSF), may stimulate the immune system in different ways and stop tumor cells from growing. Combining different types of biological therapies may kill more tumor cells. PURPOSE: This randomized phase II trial is studying giving vaccine therapy together with dendritic cells to see how well it works compared to giving vaccine therapy together with GM-CSF in treating patients with liver or lung metastases from colorectal cancer removed by surgery.

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Vaccine Therapy With or Without Sirolimus in Treating Patients With NY-ESO-1 Expressing Solid Tumors

Project description:This phase I trial studies the side effects and best schedule of vaccine therapy with or without sirolimus in treating patients with cancer-testis antigen (NY-ESO-1) expressing solid tumors. Biological therapies, such as sirolimus, may stimulate the immune system in different ways and stop tumor cells from growing. Vaccines made from a person’s white blood cells mixed with tumor proteins may help the body build an effective immune response to kill tumor cells that express NY-ESO-1. Infusing the vaccine directly into a lymph node may cause a stronger immune response and kill more tumor cells. It is not yet known whether vaccine therapy works better when given with or without sirolimus in treating solid tumors.

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2011-11-22 | E-GEOD-31256 | biostudies-arrayexpress

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