Haploidentical Donor Bone Marrow Transplant in Treating Patients With High-Risk Hematologic Cancer

ABSTRACT: This phase II trial studies how well giving fludarabine phosphate, cyclophosphamide, tacrolimus, mycophenolate mofetil and total-body irradiation together with a donor bone marrow transplant works in treating patients with high-risk hematologic cancer. Giving low doses of chemotherapy, such as fludarabine phosphate and cyclophosphamide, and total-body irradiation before a donor bone marrow transplant helps stop the growth of cancer cells by stopping them from dividing or killing them. Giving cyclophosphamide after transplant may also stop the patient’s immune system from rejecting the donor’s bone marrow stem cells. The donated stem cells may replace the patient’s immune system cells and help destroy any remaining cancer cells (graft-versus-tumor effect). Sometimes the transplanted cells from a donor can also make an immune response against the body’s normal cells. Giving tacrolimus and mycophenolate mofetil after the transplant may stop this from happening

DISEASE(S): Recurrent Childhood Small Noncleaved Cell Lymphoma,Lymphoma, Large-cell, Immunoblastic,Lymphoproliferative Disorders,Recurrent Childhood Anaplastic Large Cell Lymphoma,Stage Iv Adult Diffuse Mixed Cell Lymphoma,Childhood Burkitt Lymphoma,Stage Iv Adult Immunoblastic Large Cell Lymphoma,Recurrent Grade 1 Follicular Lymphoma,Stage Iv Chronic Lymphocytic Leukemia,Refractory Chronic Lymphocytic Leukemia,Mycosis Fungoides,Stage Iv Adult Lymphoblastic Lymphoma,Stage Iii Adult Burkitt Lymphoma,Previously Treated Myelodysplastic Syndromes,Recurrent Adult Burkitt Lymphoma,Leukemia, T-cell,Lymphomatoid Granulomatosis,De Novo Myelodysplastic Syndromes,Lymphoma, T-cell, Peripheral,Stage Iv Mycosis Fungoides/sezary Syndrome,Preleukemia,Lymphoma, B-cell, Marginal Zone,Leukemia, Myelogenous, Chronic, Bcr-abl Positive,Nodal Marginal Zone B-cell Lymphoma,Recurrent Small Lymphocytic Lymphoma,Adult Acute Myeloid Leukemia With Inv(16)(p13;q22),Lymphoma, T-cell, Cutaneous,Adult Acute Myeloid Leukemia With Del(5q),Stage Iv Adult Burkitt Lymphoma,Stage Iii Adult T-cell Leukemia/lymphoma,Stage Iii Adult Diffuse Large Cell Lymphoma,Lymphoma, Follicular,Waldenstrom Macroglobulinemia,Leukemia, Myeloid, Accelerated Phase,Hematopoietic/lymphoid Cancer,Recurrent Mantle Cell Lymphoma,Relapsing Chronic Myelogenous Leukemia,Stage Iii Cutaneous T-cell Non-hodgkin Lymphoma,Childhood Chronic Myelogenous Leukemia,Leukemia,Hodgkin Disease,Recurrent Adult Hodgkin Lymphoma,Mycoses,Recurrent Adult Lymphoblastic Lymphoma,Recurrent Childhood Large Cell Lymphoma,Leukemia, Myeloid, Acute,Stage Ii Multiple Myeloma,Testicular Lymphoma,Lymphoma, T-cell,Myelodysplastic Syndromes,Stage Iv Grade 3 Follicular Lymphoma,Leukemia, Myeloid,Immunoblastic Lymphadenopathy,Stage Iii Multiple Myeloma,Refractory Multiple Myeloma,Recurrent Adult Diffuse Mixed Cell Lymphoma,Stage Iv Grade 2 Follicular Lymphoma,Recurrent Adult T-cell Leukemia/lymphoma,Stage Iv Cutaneous T-cell Non-hodgkin Lymphoma,Childhood Acute Lymphoblastic Leukemia In Remission,Lymphoma, Non-hodgkin,Recurrent Adult Diffuse Large Cell Lymphoma,Lymphoma, B-cell,Extranodal Marginal Zone B-cell Lymphoma Of Mucosa-associated Lymphoid Tissue,Lymphoma, Large B-cell, Diffuse,Stage Iii Chronic Lymphocytic Leukemia,Stage Iv Adult T-cell Leukemia/lymphoma,Stage Iv Adult Diffuse Large Cell Lymphoma,Small Intestine Lymphoma,Childhood Acute Myeloid Leukemia In Remission,Sezary Syndrome,Adult Nasal Type Extranodal Nk/t-cell Lymphoma,Splenic Marginal Zone Lymphoma,Lymphoma, Mantle-cell,Leukemia-lymphoma, Adult T-cell,Adult Acute Myeloid Leukemia In Remission,Stage Iii Adult Diffuse Small Cleaved Cell Lymphoma,Recurrent Adult Immunoblastic Large Cell Lymphoma,Multiple Myeloma,Stage Iv Grade 1 Follicular Lymphoma,Stage Iv Mantle Cell Lymphoma,Recurrent Childhood Lymphoblastic Lymphoma,Lymphoma, Extranodal Nk-t-cell,Plasmablastic Lymphoma,Burkitt Lymphoma,Stage Iii Mycosis Fungoides/sezary Syndrome,Recurrent Adult Diffuse Small Cleaved Cell Lymphoma,Stage Iii Grade 1 Follicular Lymphoma,Stage Iii Adult Immunoblastic Large Cell Lymphoma,Post-transplant Lymphoproliferative Disorder,Adult Acute Myeloid Leukemia With T(8;21)(q22;q22),Stage Iii Marginal Zone Lymphoma,Stage Iii Adult Diffuse Mixed Cell Lymphoma,Adult Acute Myeloid Leukemia With 11q23 (mll) Abnormalities,Recurrent Marginal Zone Lymphoma,Recurrent Adult Grade Iii Lymphomatoid Granulomatosis,Leukemia, Lymphocytic, Chronic, B-cell,Intraocular Lymphoma,Neoplasms, Plasma Cell,Recurrent Grade 3 Follicular Lymphoma,Stage Iii Adult Hodgkin Lymphoma,Accelerated Phase Chronic Myelogenous Leukemia,Stage Iii Grade 2 Follicular Lymphoma,Adult Acute Lymphoblastic Leukemia In Remission,Waldenström Macroglobulinemia,Recurrent Childhood Grade Iii Lymphomatoid Granulomatosis,Angioimmunoblastic T-cell Lymphoma,Stage Iv Marginal Zone Lymphoma,Lymphoma, Large-cell, Anaplastic,Stage Iv Adult Hodgkin Lymphoma,Stage Iii Mantle Cell Lymphoma,Stage Iii Grade 3 Follicular Lymphoma,Adult Acute Myeloid Leukemia With T(16;16)(p13;q22),Hepatosplenic T-cell Lymphoma,Secondary Myelodysplastic Syndromes,Leukemia, Lymphoid,Stage Iv Adult Diffuse Small Cleaved Cell Lymphoma,Precursor Cell Lymphoblastic Leukemia-lymphoma,Recurrent Cutaneous T-cell Non-hodgkin Lymphoma,Stage Iv Small Lymphocytic Lymphoma,Lymphoma,Childhood Nasal Type Extranodal Nk/t-cell Lymphoma,Recurrent Mycosis Fungoides/sezary Syndrome,Childhood Myelodysplastic Syndromes,Stage Iv Childhood Hodgkin Lymphoma,Anaplastic Large Cell Lymphoma,Stage Iii Small Lymphocytic Lymphoma,Recurrent Grade 2 Follicular Lymphoma,Adult Acute Myeloid Leukemia With T(15;17)(q22;q12),Peripheral T-cell Lymphoma,Stage Iii Adult Lymphoblastic Lymphoma,Recurrent/refractory Childhood Hodgkin Lymphoma,Cutaneous B-cell Non-hodgkin Lymphoma,Stage Iii Childhood Hodgkin Lymphoma

PROVIDER: 2008483 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR