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Phase II Trial of FOLFOX6, Bevacizumab and Cetuximab in Patients With Colorectal Cancer

ABSTRACT: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab and cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of colorectal cancer by blocking blood flow to the tumor. Giving combination chemotherapy together with bevacizumab and cetuximab may kill more tumor cells. This phase II trial is studying how well giving combination chemotherapy together with bevacizumab and cetuximab works in treating patients with stage IV colorectal cancer that cannot be removed by surgery.

DISEASE(S): Adenocarcinoma,Stage Iv Colon Cancer,Recurrent Colon Cancer,Rectal Neoplasms,Stage Iv Rectal Cancer,Adenocarcinoma Of The Rectum,Cystadenocarcinoma,Signet Ring Adenocarcinoma Of The Colon,Adenocarcinoma, Mucinous,Mucinous Adenocarcinoma Of The Colon,Recurrent Rectal Cancer,Colonic Neoplasms

PROVIDER: 2012075 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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