Obatoclax Mesylate, Vincristine Sulfate, Doxorubicin Hydrochloride, and Dexrazoxane Hydrochloride in Treating Young Patients With Relapsed or Refractory Solid Tumors, Lymphoma, or Leukemia

ABSTRACT: This phase I trial is studying the side effects and best dose of obatoclax mesylate when given together with vincristine sulfate, doxorubicin hydrochloride, and dexrazoxane hydrochloride in treating young patients with relapsed or refractory solid tumors, lymphoma, or leukemia. Obatoclax mesylate may stop the growth of cancer cells by blocking some of the proteins needed for cell growth and causing the cells to self-destruct. Drugs used in chemotherapy, such as vincristine sulfate, doxorubicin hydrochloride, and dexrazoxane hydrochloride, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving obatoclax mesylate together with combination chemotherapy may kill more cancer cells.

DISEASE(S): Recurrent Childhood Small Noncleaved Cell Lymphoma,Lymphoma, Large B-cell, Diffuse,Blastic Phase Chronic Myelogenous Leukemia,Lymphoma, Large-cell, Immunoblastic,Recurrent Childhood Anaplastic Large Cell Lymphoma,Small Intestine Lymphoma,Childhood Burkitt Lymphoma,Refractory Hairy Cell Leukemia,Sezary Syndrome,Leukemia, Hairy Cell,Childhood Immunoblastic Large Cell Lymphoma,Refractory Chronic Lymphocytic Leukemia,Mycosis Fungoides,Recurrent Childhood Acute Myeloid Leukemia,Lymphomatoid Granulomatosis,Recurrent Childhood Lymphoblastic Lymphoma,Lymphoma, T-cell, Peripheral,Lymphoma, Extranodal Nk-t-cell,Plasmablastic Lymphoma,Burkitt Lymphoma,Leukemia, Myelogenous, Chronic, Bcr-abl Positive,Acute Leukemias Of Ambiguous Lineage,Acute Undifferentiated Leukemia,Childhood Diffuse Large Cell Lymphoma,Lymphoma, T-cell, Cutaneous,Leukemia, Lymphocytic, Chronic, B-cell,Intraocular Lymphoma,Relapsing Chronic Myelogenous Leukemia,Unspecified Childhood Solid Tumor, Protocol Specific,Recurrent Childhood Acute Lymphoblastic Leukemia,Childhood Chronic Myelogenous Leukemia,Leukemia,Mycoses,Recurrent Childhood Grade Iii Lymphomatoid Granulomatosis,Angioimmunoblastic T-cell Lymphoma,Noncutaneous Extranodal Lymphoma,Recurrent Childhood Large Cell Lymphoma,Lymphoma, Large-cell, Anaplastic,Lymphoma, T-cell,Blast Crisis,Hepatosplenic T-cell Lymphoma,Leukemia, Myeloid,Immunoblastic Lymphadenopathy,Precursor Cell Lymphoblastic Leukemia-lymphoma,Recurrent Cutaneous T-cell Non-hodgkin Lymphoma,Lymphoma,Childhood Nasal Type Extranodal Nk/t-cell Lymphoma,Recurrent Mycosis Fungoides/sezary Syndrome,Peripheral T-cell Lymphoma,Lymphoma, Non-hodgkin,Lymphoma, B-cell,Recurrent/refractory Childhood Hodgkin Lymphoma,Cutaneous B-cell Non-hodgkin Lymphoma

PROVIDER: 2074742 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR