High-Dose Busulfan and High-Dose Cyclophosphamide Followed By Donor Bone Marrow Transplant in Treating Patients With Leukemia, Myelodysplastic Syndrome, Multiple Myeloma, or Recurrent Hodgkin or Non-Hodgkin Lymphoma

ABSTRACT: RATIONALE: Giving high doses of chemotherapy drugs, such as busulfan and cyclophosphamide, before a donor bone marrow transplant helps stop the growth of cancer cells. It may also stop the patient’s immune system from rejecting the donor’s stem cells. When the healthy stem cells from a donor are infused into the patient they may help the patient’s bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body’s normal cells. Giving cyclosporine, methylprednisolone, and methotrexate after transplant may stop this from happening. PURPOSE: This clinical trial studies high-dose busulfan and high-dose cyclophosphamide followed by donor bone marrow transplant in treating patients with leukemia, myelodysplastic syndrome, multiple myeloma, or recurrent Hodgkin or Non-Hodgkin lymphoma.

DISEASE(S): Lymphoma, Large-cell, Immunoblastic,Adult Acute Myeloblastic Leukemia With Maturation (m2),Lymphoproliferative Disorders,Adult Acute Promyelocytic Leukemia (m3),Childhood Acute Megakaryocytic Leukemia (m7),Childhood Acute Monocytic Leukemia (m5b),Recurrent Grade 1 Follicular Lymphoma,Mycosis Fungoides,Previously Treated Myelodysplastic Syndromes,Recurrent Adult Burkitt Lymphoma,Leukemia, T-cell,Lymphomatoid Granulomatosis,Leukemia, Myelomonocytic, Acute,De Novo Myelodysplastic Syndromes,Lymphoma, T-cell, Peripheral,Preleukemia,Lymphoma, B-cell, Marginal Zone,Leukemia, Myelogenous, Chronic, Bcr-abl Positive,Adult Erythroleukemia (m6a),Nodal Marginal Zone B-cell Lymphoma,Recurrent Small Lymphocytic Lymphoma,Adult Acute Myeloid Leukemia With Inv(16)(p13;q22),Lymphoma, T-cell, Cutaneous,Adult Acute Myeloid Leukemia With Del(5q),Lymphoma, Follicular,Waldenstrom Macroglobulinemia,Leukemia, Myeloid, Accelerated Phase,Recurrent Mantle Cell Lymphoma,Relapsing Chronic Myelogenous Leukemia,Recurrent Childhood Acute Lymphoblastic Leukemia,Chronic Phase Chronic Myelogenous Leukemia,Childhood Chronic Myelogenous Leukemia,Leukemia,Hodgkin Disease,Recurrent Adult Hodgkin Lymphoma,Mycoses,Recurrent Adult Lymphoblastic Lymphoma,Leukemia, Myeloid, Acute,Leukemia, Myelomonocytic, Chronic,Testicular Lymphoma,Leukemia, Monocytic, Acute,Childhood Acute Myeloblastic Leukemia Without Maturation (m1),Adult Acute Myelomonocytic Leukemia (m4),Lymphoma, T-cell,Myelodysplastic Syndromes,Recurrent Adult Acute Myeloid Leukemia,Leukemia, Myeloid,Immunoblastic Lymphadenopathy,Refractory Multiple Myeloma,Childhood Acute Monoblastic Leukemia (m5a),Recurrent Adult Diffuse Mixed Cell Lymphoma,Recurrent Adult T-cell Leukemia/lymphoma,Childhood Acute Lymphoblastic Leukemia In Remission,Lymphoma, Non-hodgkin,Recurrent Adult Diffuse Large Cell Lymphoma,Lymphoma, B-cell,Lymphoma, Large B-cell, Diffuse,Extranodal Marginal Zone B-cell Lymphoma Of Mucosa-associated Lymphoid Tissue,Adult Acute Megakaryoblastic Leukemia (m7),Leukemia, Myeloid, Chronic-phase,Small Intestine Lymphoma,Childhood Acute Myeloid Leukemia In Remission,Childhood Acute Myeloblastic Leukemia With Maturation (m2),Sezary Syndrome,Adult Nasal Type Extranodal Nk/t-cell Lymphoma,Splenic Marginal Zone Lymphoma,Lymphoma, Mantle-cell,Leukemia-lymphoma, Adult T-cell,Adult Acute Myeloid Leukemia In Remission,Recurrent Adult Immunoblastic Large Cell Lymphoma,Recurrent Childhood Acute Myeloid Leukemia,Multiple Myeloma,Leukemia, Megakaryoblastic, Acute,Lymphoma, Extranodal Nk-t-cell,Plasmablastic Lymphoma,Adult Pure Erythroid Leukemia (m6b),Burkitt Lymphoma,Recurrent Adult Non-hodgkin Lymphoma,Adult Acute Myeloblastic Leukemia Without Maturation (m1),Recurrent Adult Diffuse Small Cleaved Cell Lymphoma,Post-transplant Lymphoproliferative Disorder,Adult Acute Myeloid Leukemia With T(8;21)(q22;q22),Adult Acute Myeloid Leukemia With 11q23 (mll) Abnormalities,Recurrent Marginal Zone Lymphoma,Recurrent Adult Grade Iii Lymphomatoid Granulomatosis,Leukemia, Lymphocytic, Chronic, B-cell,Intraocular Lymphoma,Neoplasms, Plasma Cell,Recurrent Grade 3 Follicular Lymphoma,Recurrent Adult Acute Lymphoblastic Leukemia,Childhood Acute Erythroleukemia (m6),Accelerated Phase Chronic Myelogenous Leukemia,Adult Acute Lymphoblastic Leukemia In Remission,Angioimmunoblastic T-cell Lymphoma,Childhood Acute Promyelocytic Leukemia (m3),Leukemia, Promyelocytic, Acute,Lymphoma, Large-cell, Anaplastic,Childhood Acute Myelomonocytic Leukemia (m4),Adult Acute Myeloid Leukemia With T(16;16)(p13;q22),Hepatosplenic T-cell Lymphoma,Secondary Myelodysplastic Syndromes,Leukemia, Lymphoid,Precursor Cell Lymphoblastic Leukemia-lymphoma,Recurrent Cutaneous T-cell Non-hodgkin Lymphoma,Lymphoma,Recurrent Mycosis Fungoides/sezary Syndrome,Childhood Myelodysplastic Syndromes,Adult Acute Monocytic Leukemia (m5b),Anaplastic Large Cell Lymphoma,Adult Acute Monoblastic Leukemia (m5a),Recurrent Grade 2 Follicular Lymphoma,Peripheral T-cell Lymphoma,Adult Acute Myeloid Leukemia With T(15;17)(q22;q12),Leukemia, Erythroblastic, Acute,Cutaneous B-cell Non-hodgkin Lymphoma

PROVIDER: 2093228 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR