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Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma

ABSTRACT: RATIONALE: Drugs used in chemotherapy, such as doxorubicin hydrochloride and trabectedin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether trabectedin is more effective than doxorubicin hydrochloride in treating patients with advanced or metastatic soft tissue sarcoma. PURPOSE: This randomized phase II/III trial is studying the safety of trabectedin compared with doxorubicin hydrochloride and to see how well they work in treating patients with advanced or metastatic soft tissue sarcoma.

DISEASE(S): Soft Tissue Sarcomas,Histologically Proven Advanced And/or Metastatic Malignant Soft Tissue Sarcoma Intermediate/high Grade, Excluding The Following Tumor Types : Well-differentiated Liposarcoma Embryonal Rhabdomyosarcoma Chondrosarcoma (excluding Extraskeletal Myxoid Chondrosarcoma) Osteosarcoma (excluding Extraskeletal Osteosarcoma) Ewing Tumors / Primitive Neuroectodermal Tumor (pnet) Gastro-intestinal Stromal Tumors (gist) Dermatofibrosarcoma Protuberans,Sarcoma,Histologically Proven Advanced And/or Metastatic Malignant Soft Tissue Sarcoma Intermediate/high Grade, Excluding The Following Tumor Types : Well-differentiated Liposarcoma Embryonal Rhabdomyo...

PROVIDER: 2094138 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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