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Trial of Metformin for Colorectal Cancer Risk Reduction for History of Colorectal Adenomas and Elevated BMI

ABSTRACT: The purpose of this study is to find out whether METFORMIN decreases protein markers in colorectal tissue. This is a phase IIA study of the pharmacodynamics, safety and tolerability of Metformin in decreasing colorectal mucosa in patients with a history of colorectal adenomas in the past 3 years and a BMI >= 30, with decimals rounded to the nearest whole integer. Metformin as a potential chemopreventive agent for inhibition of the relevant molecular pathways involved in human colorectal carcinogenesis.

DISEASE(S): Adenomatous Polyp,Adenomatous Polyps,Obesity,Colorectal Cancer,Colorectal Neoplasms,Adenoma

PROVIDER: 2103542 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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