Vaccine Therapy With or Without Sirolimus in Treating Patients With NY-ESO-1 Expressing Solid Tumors

ABSTRACT: This phase I trial studies the side effects and best schedule of vaccine therapy with or without sirolimus in treating patients with cancer-testis antigen (NY-ESO-1) expressing solid tumors. Biological therapies, such as sirolimus, may stimulate the immune system in different ways and stop tumor cells from growing. Vaccines made from a person’s white blood cells mixed with tumor proteins may help the body build an effective immune response to kill tumor cells that express NY-ESO-1. Infusing the vaccine directly into a lymph node may cause a stronger immune response and kill more tumor cells. It is not yet known whether vaccine therapy works better when given with or without sirolimus in treating solid tumors.

DISEASE(S): Stage Iia Breast Cancer,Stage Ia Ovarian Cancer,Recurrent Esophageal Carcinoma,Carcinoma,Stage Iv Skin Melanoma,Urinary Bladder Neoplasms,Stage Ia Uterine Corpus Cancer,Breast Neoplasms,Stage Ib Breast Cancer,Stage Iiic Ovarian Cancer,Stage Iiic Breast Cancer,Brain Neoplasms,Stage Iv Prostate Cancer,Esophageal Neoplasms,Estrogen Receptor Positive,Recurrent Breast Carcinoma,Stage Ii Uterine Corpus Cancer,Carcinoma, Renal Cell,Stomach Neoplasms,Recurrent Renal Cell Carcinoma,Stage Iib Skin Melanoma,Hormone-resistant Prostate Cancer,Stage Iic Ovarian Cancer,Melanoma,Stage Iiib Breast Cancer,Stage Iiia Uterine Corpus Cancer,Stage Iia Lung Carcinoma,Stage Iiic Skin Melanoma,Stage Iib Ovarian Cancer,Stage Iva Uterine Corpus Cancer,Estrogen Receptor Negative,Skin Neoplasms,Carcinoma, Hepatocellular,Recurrent Bladder Carcinoma,Stage Iib Lung Carcinoma,Stage Ivb Uterine Corpus Cancer,Stage Iia Ovarian Cancer,Recurrent Gastric Carcinoma,Stage Iiic Uterine Corpus Cancer,Stage Iiia Breast Cancer,Glioblastoma,Stage Iiia Skin Melanoma,Anaplastic Astrocytoma,Lung Neoplasms,Stage Iiib Esophageal Cancer,Prostatic Neoplasms,Metastatic Renal Cell Cancer,Stage Iiib Skin Melanoma,Stage Iv Ovarian Cancer,Stage Iiia Esophageal Cancer,Stage Iv Bladder Urothelial Carcinoma,Recurrent Ovarian Carcinoma,Stage Iv Esophageal Cancer,Colorectal Neoplasms,Ovarian Neoplasms,Stage Iiib Uterine Corpus Cancer,Stage Iiib Ovarian Cancer,Astrocytoma,Metastatic Prostate Carcinoma,Stage Iiic Esophageal Cancer,Sarcoma,Recurrent Colorectal Carcinoma,Recurrent Hepatocellular Carcinoma,Stage Ia Breast Cancer,Stage Ic Ovarian Cancer,Recurrent Lung Carcinoma,Stage Iib Esophageal Cancer,Stage Iiia Ovarian Cancer,Oligodendroglioma,Recurrent Adult Brain Neoplasm,Stage Iic Skin Melanoma,Anaplastic Oligodendroglioma,Stage Iiia Lung Carcinoma,Recurrent Prostate Carcinoma,Recurrent Uterine Corpus Carcinoma,Carcinoma, Ovarian Epithelial,Stage Ib Uterine Corpus Cancer,Stage Ib Ovarian Cancer,Stage Iib Breast Cancer,Anaplastic Oligoastrocytoma,Recurrent Melanoma,Resectable Hepatocellular Carcinoma

PROVIDER: 2119578 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR