Browse
Submit Data
Databases
API
Help

Dataset Information

8 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Evaluation of Reduced-volume PEG Bowel Preparation Administered the Same Day of Colonoscopy

ABSTRACT: The conventional total dose of 4 L of polyethylene glycol (PEG) given the day before the procedure is safe and effective. It has been the standard cleansing regimen for the last 25 years. To overcome the difficulty in completing the bowel preparation due to large volume and/or taste, reduced-volume (mixed) bowel preparation of bisacodyl and 2 L of PEG have been shown to provide adequate colon cleansing and better tolerability. LoVol-esse is a reduced-volume PEG-based bowel preparation to be used in combination with bisacodyl and designed to improve patient tolerability and attitude toward bowel cleansing prior to colonoscopy thanks to the reduced volume and improved taste. The present study is intended to compare the new dosing regimen of the bowel lavage solution given the same day compared with standard PEG formulation (SELG 1000) given the day before colonoscopy.

DISEASE(S): Colonic Polyps,Inflammatory Bowel Diseases,Cancer Colon,Inflammatory Bowel Disease

PROVIDER: 2120359 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Efficacy of 2-Liter Mixed Preparation With Bisacodyl Plus Polyethylene Glycol and 4-Liter Polyethylene Glycol for Colon Cleansing in Patients With Prior History of Colorectal Resection

Project description:Studies that have investigated different bowel preparations in patients with history of colorectal surgery are surprisingly lacking.Therefore, which is the best colon preparation in this subgroup of patients is still unknown. Polyethylene glycol (PEG)-based solutions are the most popular and safest bowel preparation regimens, however the 4-Liter volume is often poorly tolerated. More recently, it has been shown that the use of a low volume preparation (2-Liter PEG solution with the adjunct of a laxative, bisacodyl) achieves comparable bowel cleanliness rates to 4-Liter PEG in general population.The primary aim will be to compare the efficacy of 2-L mixed preparation (bisacodyl plus PEG) to 4-L PEG preparation.

| 2147376 | ecrin-mdr-crc

A Randomized Prospective Trial Comparing Polyethylene Glycol and Sodium Picosulphate With Magnesium Citrate

Project description:Adequate bowel cleansing is important for a completeness of colonoscopy and detection of colon polyps. Inadequate bowel preparation leads to longer duration of colonoscopy and obscured mucosal visualization resulting in missed lesions. Bowel cleansing agents are simply classified into the large volume, iso-osmotic polyethylene glycol (PEG) based solutions or the small volume osmotically active agents, such as sodium picosulphate with magnesium citrate (SPMC). There are rare reports that compare directly conventional polyethylene glycol (PEG) solution and sodium picosulphate with magnesium citrate (SPMC) for bowel preparation in korea. The aim of this study is to compare the efficacy, safety, and tolerability of different regimens of SPMC and PEG solution.

| 2139045 | ecrin-mdr-crc

Yoga and Bolus Lukewarm Saline as Rapid Colonoscopy Preparation

Project description:A quality colonoscopy examination remains as the gold standard for colorectal cancer screening, but effective large bowel cleansing prior to colonoscopy is still not achieved in all cases that undergo the procedure. Currently, the most widely used cleansing methods employ balanced electrolyte-polyethylene glycol (PEG) solutions. However, a very large volume of PEG solution is required for it to be effective, and many patients refuse to drink a sufficient amount due to non-palatability. In this study, the investigators compare a novel colon preparation method--bolus lukewarm saline with yoga exercise--with a PEG based solution (HalfLytely) for large bowel cleansing.

| 2121430 | ecrin-mdr-crc

Effect of Simethicone on Bowel Preparation for Colonoscopy

Project description:Optimal bowel preparation is essential for colonoscopy efficacy and safety. Mucosal visualization during colonoscopy is often limited by residual stool, bubbles, bile, intraluminal fluid, and debris, which increase the risk of missing flat adenomas or other small lesions.Therefore, intestinal preparation is necessary to remove residual materials prior to endoscopy. A combined agent, low-dose PEG with ascorbic acid (PEG-Asc), is one low-volume solution commonly used in Korea (Coolprep; TaeJoon Pharmaceuticals, Seoul, Korea). However, practitioners have noted an increased incidence of bubble formation with this preparation method. To the investigators knowledge, no previous study has assessed colon preparation in patients administered simethicone. The purpose of this study was to compare the quality of bowel preparation and compliance between PEG-Asc and PEG-Asc with simethicone. The effectiveness of adding simethicone as an antifoaming agent to improve bowel cleansing for colonoscopy was evaluated in terms of bowel preparation scale and bubble score, and the compliance of both patients and endoscopists was also investigated using a questionnaire.

| 2198002 | ecrin-mdr-crc

Effect of Adding Simethicone to Split-dose Polyethylene Glycol for Bowel Preparation in a Screening Colonoscopy Setting

Project description:Colonoscopy is currently accepted as the gold standard in screening, surveillance and prevention for colorectal cancer (CRC), and therefore, its quality is a major priority. The quality of colonoscopy is greatly dependent on the quality of the bowel preparation. Standard bowel cleansing includes a low-fibre diet on the day preceding the exam and a split regimen of 4 litres of polyethylene glycol (PEG) solution. In order to improve bowel cleansing some additional measures are available. Simethicone is an inexpensive and safe antifoaming agent that reduces the surface tension of air bubbles, theoretically presenting several benefits such as increased tolerability to the preparation, thereby improving the quality of the preparation and, secondly, adenoma detection (ADR) and cecal intubation rates (CIR). However, its role remains controversial, with some publications supporting its administration and others failing to demonstrate clear benefits. The main aim of this study is to assess if addition of simethicone to a split-dose cleansing regimen of 4 litres of PEG improves adequate bowel preparation rate.

| 2295328 | ecrin-mdr-crc

Evaluating the effect of bowel preparation plus oral Rifaximin in Brachytherapy for endometrial and cervical Cancer

Project description:Intervention 1: Intervention group: bowel preparation with polyethilenglycol and bisacodyl tablet since 24 hours befor trearment and also rifaximin 400 mg BD since 7 days befor treatment. Intervention 2: Control group: bowel preparation with polyethilenglycol and bisacodyl tablet since 24 hours befor trearment. Primary outcome(s): Rectal volume. Timepoint: Before(basement) and 7 days after oral Rifaximin. Method of measurement: HDR plus 3.0.8 brachytherapy , treatment planning, Bebig & Ziegler company.;Rectal Dose-volume parameters. Timepoint: Before(basement) and 7 days after oral Rifaximin. Method of measurement: HDR plus 3.0.8 brachytherapy treatment planning, Bebig & Ziegler company. Study Design: Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention.

| 2501076 | ecrin-mdr-crc

Comparison of the Effectiveness of Bowel Preparations Before Colonoscopy

Project description:Polyethylene glycol is the gold standard of bowel preparation for colonoscopy. The most important disadvantage is high volume of this preparation. Sulphate based solution (SBS), low volume PEG + ascorbic acid and solution of magnesium citric acid and sodium picosulfate could be suitable substitution of polyethylene glycol.

| 2251227 | ecrin-mdr-crc

A trial to compare efficacy and tolerability of Plenvu and Picoprep as cleansing agents of the large bowel before colonoscopy (examination ofthe bowel with a fiberoptic device)

Project description:Primary objectives: Aim of the study is to compare the efficacy and tolerability of the relatively new bowel preparation Plenvu with the well established bowel preparation Picoprep as cleansing agents before colonoscopy. This is to test whether the low volume Polyethylin Glycol-electrolytes lavage solution preparation Plenvu would have non-inferior efficacy on bowel preparation compared with Picosulfate based Picoprep with a better effect on compliance and tolerability. Primary endpoints: The primary endpoint is the efficacy of cleansing preparations measured by the quality of cleansing. This is done using the validated Harfield Cleansing Scale. The cleansing quality is measured after dividing the colon into 5 segments (Rectum, sigmoid colon, Descending colon, Transverse colon, and Ascending colon/Cecum) and each segment is scored from 0 (irremovable heavy hard stool) to 4 (empty and clean), then a total grade is given. Grade A (all segments scored 3 or 4) and B (one or more segments scored 2) are considered as successful cleansing. Grade C (one or more segments scored 1) and D (one or more segments scored 0) is considered unsuccessful cleansing8.

| 2736088 | ecrin-mdr-crc

Efficacy, Safety and Tolerability of Eziclen/Izinova Versus Klean-prep on Bowel Cleansing in Adolescents Undergoing Colonoscopy

Project description:The purpose of the protocol is to demonstrate that Eziclen/Izinova, an osmotic sulphate-based laxative preparation given on the day before colonoscopy has non-inferior efficacy to Klean-Prep (polyethylene glycol (PEG)-electrolytes) on colon cleansing in adolescents aged 12 to 17 years (inclusive) with a body weight >40 kg, scheduled to undergo a colonoscopy for a routinely accepted diagnostic indication.

| 2233266 | ecrin-mdr-crc

Combination Lubiprostone and Split-Dose PEG-ELS Vs Split-Dose PEG-ELS alone for bowel preparation before colonoscopy in constipated patients: A prospective, endoscopist-blinded, randomized controlled trial

Project description:Interventions: split-dose PEG-ELS combination with Lubiprostone 3 times by specifying as follows; 2 days before colonoscopy 1 capsule of Lubiprostone at 6.00 a.m. then took 1 capsule of Lubiprostone at 6 p.m. Day before colonoscopy - 1 capsule of Lubiprostone at 6.00 a.m. The subjects would receive 1 sachet of PEG-ELS mixed with 2 liters of water, which the patients had to take all within 2 hours at 6:00 p.m. Lastly, on the colonoscopy day, the subjects received 1 sachet of PEG-ELS mixed with 2 liters of water and took it all in 2 hours at 4.00 a.m. on the day of the colonoscopy.,split-dose PEG-ELS before colonoscopy day, patients had to take 1 sachet of PEG-ELS with 2 Liter of water at 6 p.m. and 1 sachet of PEG-ELS with 2 Liter of water at 4 a.m. on the day of the colonoscopy.;Active Comparator Drug,Placebo Comparator Drug;split-dose PEG-ELS combination with Lubiprostone 3 times ,split-dose PEG-ELS combination Primary outcome(s): the Ottawa bowel preparation score Colonoscopy day proportion of adequate bowel cleansing Study Design: Randomized

| 56421 | ecrin-mdr-crc

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data