First-line Irinotecan, Lederfolin and 5FU (FOLFIRI) and Bevacizumab in Patients With Advanced Colorectal Cancer

ABSTRACT: Bevacizumab in combination with chemotherapy represents a standard of care for first-line treatment in patients with advanced colorectal cancer. Molecular predictive factors for bevacizumab efficacy have not yet been identified therefore selection of patients more likely to benefit from such a treatment approach is not possible. Retrospective analyses suggested that LDH serum levels may influence the clinical activity of anti-angiogenetic drugs. Primary aim of our clinical trial will be to prospectively ascertain whether bevacizumab in combination with chemotherapy has an improved clinical activity in patients with high LDH serum levels compared to patients with normal LDH serum levels

DISEASE(S): Patients Treated With First-line Chemotherapy And Bevacizumab Will Be Prospectively Stratified According To Ldh Serum Levels,Pazienti Trattati Con Bevacizumab E Chemioterapia In Prima Linea Saranno Stratificati Prospetticamente In Base Ai Livelli Sierici Di Ldh,Colorectal Cancer,Colorectal Neoplasms,Colorectal Cancer Stage Ii

PROVIDER: 2144826 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR