Ibrutinib in Treating Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma in Patients With HIV Infection

ABSTRACT: This phase I trial studies the side effects and best dose of ibrutinib in treating B-cell non-Hodgkin lymphoma that has returned or does not respond to treatment in patients with human immunodeficiency virus (HIV) infection. Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. It is not yet known whether it is safe for patients with HIV infection to receive ibrutinib while also taking anti-HIV drugs.

DISEASE(S): Lymphoma, Large B-cell, Diffuse,Lymphoma, Large-cell, Immunoblastic,Hyperplasia,Adult B Acute Lymphoblastic Leukemia,Recurrent Grade 1 Follicular Lymphoma,Refractory Hairy Cell Leukemia,Chronic Lymphocytic Leukemia,Splenic Marginal Zone Lymphoma,Leukemia, Hairy Cell,Acquired Immunodeficiency Syndrome,Refractory Chronic Lymphocytic Leukemia,Lymphoma, Mantle-cell,Hiv Infection,Recurrent Adult Burkitt Lymphoma,Multiple Myeloma,Multicentric Angiofollicular Lymphoid Hyperplasia,Lymphomatoid Granulomatosis,Plasmablastic Lymphoma,Lymphoma, B-cell, Marginal Zone,Burkitt Lymphoma,Hiv Infections,Recurrent Adult Diffuse Small Cleaved Cell Lymphoma,Extranodal Marginal Zone Lymphoma Of Mucosa-associated Lymphoid Tissue,Recurrent Small Lymphocytic Lymphoma,Refractory Plasma Cell Myeloma,Recurrent Marginal Zone Lymphoma,Recurrent Adult Grade Iii Lymphomatoid Granulomatosis,Lymphoma, Follicular,Waldenstrom Macroglobulinemia,Recurrent Adult Immunoblastic Lymphoma,Small Intestinal Lymphoma,Leukemia, Lymphocytic, Chronic, B-cell,Intraocular Lymphoma,Recurrent Mantle Cell Lymphoma,Castleman Disease,Recurrent Adult Acute Lymphoblastic Leukemia,Recurrent Grade 3 Follicular Lymphoma,Leukemia,Recurrent Adult Lymphoblastic Lymphoma,Infections,Testicular Lymphoma,Nodal Marginal Zone Lymphoma,Leukemia, Lymphoid,Precursor Cell Lymphoblastic Leukemia-lymphoma,Lymphoma,Recurrent Adult Diffuse Mixed Cell Lymphoma,Recurrent Grade 2 Follicular Lymphoma,Lymphoma, Non-hodgkin,Recurrent Adult Diffuse Large Cell Lymphoma,Lymphoma, B-cell,Cutaneous B-cell Non-hodgkin Lymphoma

PROVIDER: 2164362 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR