Lenalidomide and Combination Chemotherapy (DA-EPOCH-R) in Treating Patients With MYC-Associated B-Cell Lymphomas

ABSTRACT: This phase I/II trial studies the side effects and best dose of lenalidomide when given together with combination chemotherapy and to see how well they work in treating patients with v-myc myelocytomatosis viral oncogene homolog (avian) (MYC)-associated B-cell lymphomas. Lenalidomide may stop the growth of B-cell lymphomas by blocking the growth of new blood vessels necessary for cancer growth and by blocking some of the enzymes needed for cell growth. Biological therapies, such as lenalidomide, use substances made from living organisms that may stimulate or suppress the immune system in different ways and stop cancer cells from growing. Drugs used in chemotherapy, such as etoposide, prednisone, vincristine sulfate, doxorubicin hydrochloride, cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as rituximab, may block cancer growth in different ways by targeting certain cells. Giving lenalidomide together with combination chemotherapy may be an effective treatment in patients with B-cell lymphoma.

DISEASE(S): Stage I Chronic Lymphocytic Leukemia,Extranodal Marginal Zone B-cell Lymphoma Of Mucosa-associated Lymphoid Tissue,Lymphoma, Large B-cell, Diffuse,Adult Grade Iii Lymphomatoid Granulomatosis,Stage Iii Chronic Lymphocytic Leukemia,Stage Iv Adult Diffuse Large Cell Lymphoma,Lymphoma, Large-cell, Immunoblastic,Contiguous Stage Ii Adult Immunoblastic Large Cell Lymphoma,Stage I Adult Diffuse Small Cleaved Cell Lymphoma,Noncontiguous Stage Ii Adult Immunoblastic Large Cell Lymphoma,Small Intestine Lymphoma,Stage Iv Adult Diffuse Mixed Cell Lymphoma,Progressive Hairy Cell Leukemia, Initial Treatment,Stage Iv Adult Immunoblastic Large Cell Lymphoma,Stage I Small Lymphocytic Lymphoma,Stage Iv Chronic Lymphocytic Leukemia,Contiguous Stage Ii Marginal Zone Lymphoma,Contiguous Stage Ii Adult Diffuse Small Cleaved Cell Lymphoma,Leukemia, Hairy Cell,Splenic Marginal Zone Lymphoma,Stage I Marginal Zone Lymphoma,Lymphoma, Mantle-cell,Stage Ii Small Lymphocytic Lymphoma,Stage I Grade 1 Follicular Lymphoma,Stage Iii Adult Diffuse Small Cleaved Cell Lymphoma,Stage Iv Grade 1 Follicular Lymphoma,Stage Iv Mantle Cell Lymphoma,Lymphomatoid Granulomatosis,Stage I Adult Hodgkin Lymphoma,Stage I Adult Diffuse Mixed Cell Lymphoma,Plasmablastic Lymphoma,Lymphoma, B-cell, Marginal Zone,Stage I Mantle Cell Lymphoma,Stage I Adult Immunoblastic Large Cell Lymphoma,Stage Iii Grade 1 Follicular Lymphoma,Stage Iii Adult Immunoblastic Large Cell Lymphoma,Nodal Marginal Zone B-cell Lymphoma,Stage Iii Marginal Zone Lymphoma,Noncontiguous Stage Ii Grade 3 Follicular Lymphoma,Stage Iii Adult Diffuse Mixed Cell Lymphoma,Contiguous Stage Ii Grade 3 Follicular Lymphoma,Stage I Adult Diffuse Large Cell Lymphoma,Stage Iii Adult Diffuse Large Cell Lymphoma,Lymphoma, Follicular,Waldenstrom Macroglobulinemia,Leukemia, Lymphocytic, Chronic, B-cell,Intraocular Lymphoma,Noncontiguous Stage Ii Adult Diffuse Small Cleaved Cell Lymphoma,Stage Ii Chronic Lymphocytic Leukemia,Contiguous Stage Ii Grade 1 Follicular Lymphoma,Stage Iii Adult Hodgkin Lymphoma,Leukemia,Hodgkin Disease,Stage Iii Grade 2 Follicular Lymphoma,Contiguous Stage Ii Adult Diffuse Large Cell Lymphoma,Waldenström Macroglobulinemia,Stage Iv Marginal Zone Lymphoma,Noncontiguous Stage Ii Mantle Cell Lymphoma,Contiguous Stage Ii Adult Diffuse Mixed Cell Lymphoma,Testicular Lymphoma,Stage I Grade 3 Follicular Lymphoma,Stage Iv Adult Hodgkin Lymphoma,Contiguous Stage Ii Grade 2 Follicular Lymphoma,Stage Iii Mantle Cell Lymphoma,Noncontiguous Stage Ii Grade 2 Follicular Lymphoma,Stage 0 Chronic Lymphocytic Leukemia,Noncontiguous Stage Ii Adult Diffuse Mixed Cell Lymphoma,Stage Iii Grade 3 Follicular Lymphoma,Stage Iv Grade 3 Follicular Lymphoma,Untreated Hairy Cell Leukemia,Leukemia, Lymphoid,Stage Iv Adult Diffuse Small Cleaved Cell Lymphoma,Noncontiguous Stage Ii Marginal Zone Lymphoma,Noncontiguous Stage Ii Grade 1 Follicular Lymphoma,B-cell Chronic Lymphocytic Leukemia,Stage Iv Small Lymphocytic Lymphoma,Lymphoma,Noncontiguous Stage Ii Small Lymphocytic Lymphoma,Stage Iii Small Lymphocytic Lymphoma,Stage Ii Adult Hodgkin Lymphoma,Stage Iv Grade 2 Follicular Lymphoma,Contiguous Stage Ii Mantle Cell Lymphoma,Contiguous Stage Ii Small Lymphocytic Lymphoma,Lymphoma, Non-hodgkin,Noncontiguous Stage Ii Adult Diffuse Large Cell Lymphoma,Stage I Grade 2 Follicular Lymphoma,Lymphoma, B-cell,Cutaneous B-cell Non-hodgkin Lymphoma

PROVIDER: 2172376 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR