Rituximab, Romidepsin, and Lenalidomide in Treating Patients With Recurrent or Refractory B-cell Non-Hodgkin Lymphoma

ABSTRACT: This phase I/II trial studies the side effects and best dose of romidepsin and lenalidomide when combined with rituximab and to see how well this combination works in treating patients with B-cell non-Hodgkin lymphoma that has returned (recurrent) or did not respond to treatment (refractory). Monoclonal antibodies, such as rituximab, may block cancer growth in different ways by targeting certain cells. Romidepsin and lenalidomide may stop the growth of cancer cells by blocking enzymes needed for cell growth. Giving rituximab together with romidepsin and lenalidomide may be a better treatment for B-cell non-Hodgkin lymphoma.

DISEASE(S): Extranodal Marginal Zone B-cell Lymphoma Of Mucosa-associated Lymphoid Tissue,Recurrent Grade 3 Follicular Lymphoma,Recurrent Adult Acute Lymphoblastic Leukemia,Lymphoma, Large B-cell, Diffuse,Lymphoma, Large-cell, Immunoblastic,Leukemia,Waldenström Macroglobulinemia,Recurrent Adult Lymphoblastic Lymphoma,Small Intestine Lymphoma,Recurrent Grade 1 Follicular Lymphoma,Refractory Hairy Cell Leukemia,Testicular Lymphoma,Splenic Marginal Zone Lymphoma,Leukemia, Hairy Cell,Lymphoma, Mantle-cell,Recurrent Adult Immunoblastic Large Cell Lymphoma,Recurrent Adult Burkitt Lymphoma,Lymphomatoid Granulomatosis,Leukemia, Lymphoid,Plasmablastic Lymphoma,Precursor Cell Lymphoblastic Leukemia-lymphoma,Lymphoma, B-cell, Marginal Zone,Burkitt Lymphoma,Lymphoma,Recurrent Adult Diffuse Small Cleaved Cell Lymphoma,Nodal Marginal Zone B-cell Lymphoma,Recurrent Small Lymphocytic Lymphoma,Recurrent Adult Diffuse Mixed Cell Lymphoma,Recurrent Marginal Zone Lymphoma,Recurrent Grade 2 Follicular Lymphoma,Lymphoma, Follicular,Waldenstrom Macroglobulinemia,Recurrent Adult Grade Iii Lymphomatoid Granulomatosis,B-cell Adult Acute Lymphoblastic Leukemia,Lymphoma, Non-hodgkin,Recurrent Adult Diffuse Large Cell Lymphoma,Intraocular Lymphoma,Leukemia, Lymphocytic, Chronic, B-cell,Lymphoma, B-cell,Recurrent Mantle Cell Lymphoma

PROVIDER: 2177542 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR