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Cancer Experience Registry (CER)

ABSTRACT: The Cancer Experience Registry: An Online Survey Research Study to Understand the Experiences of Those Impacted By a Cancer Diagnosis. The Registry is a web-based platform to distribute cross-sectional and longitudinal surveys. Study surveys are designed based on input from advisor experts, including patients and caregivers, and focus on the social, emotional, physical, financial and decision-making experiences of those who have been diagnosed with cancer and their caregivers. Findings contribute toward enhancing care for patients, survivors and caregivers via programming and policy initiatives.

DISEASE(S): Ovarian Cancer,Lung Cancer,Caregiver,Melanoma,Colorectal Cancer,Prostate Cancer,Bladder Cancer,Breast Cancer,Neoplasms,Cancer,Multiple Myeloma

PROVIDER: 2181551 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan

Project description:Positive experiences, such as social interaction, cognitive training and physical exercise, have been shown to ameliorate some of the harms to cognition associated with ageing. Animal models of positive interventions, commonly known as environmental enrichment, strongly influence neuronal morphology and synaptic function and enhance cognitive performance. While the profound structural and functional benefits of enrichment have been appreciated for decades, little is known as to how the environment influences neurons to respond and adapt to these positive sensory experiences. We show that adult and aged male wild-type mice that underwent a 10-week environmental enrichment protocol demonstrated improved performance in a variety of behavioural tasks, including those testing spatial working and spatial reference memory, and an enhancement in hippocampal LTP. Aged animals in particular benefitted from enrichment, performing spatial memory tasks at levels similar to healthy adult mice. Many of these benefits, including in gene expression, were absent in mice with a mutation in an enzyme, MSK1, which is activated by BDNF, a growth factor implicated in rodent and human cognition. We conclude that enrichment is beneficial across the lifespan and that MSK1 is required for the full extent of these experience-induced improvements of cognitive abilities, synaptic plasticity and gene expression.

2023-06-20 | GSE235037 | GEO

Living With Colorectal Cancer: Patient and Caregiver Experience

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Transcription profiling of human peripheral blood CD14+ leukocytes from SRESS study particpants

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2008-06-20 | E-GEOD-7893 | biostudies-arrayexpress

Differential gene expression in peripheral blood CD14+ leukocytes from SRESS study particpants

2008-05-20 | GSE7893 | GEO

Temperature influences the composition and cytotoxicity of extracellular vesicles in Staphylococcus aureus

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2021-10-12 | PXD025236 | Pride

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2015-12-31 | E-GEOD-66795 | biostudies-arrayexpress

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2015-03-28 | GSE52319 | GEO

Experience and Enhancement: Improving Colonoscopic Polyp Detection

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2020-06-03 | GSE132755 | GEO

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