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Study of Binimetinib + Nivolumab Plus or Minus Ipilimumab in Patients With Previously Treated Microsatellite-stable (MSS) Metastatic Colorectal Cancer With RAS Mutation

ABSTRACT: This is a multicenter, open-label, Phase 1B/2 study to evaluate the safety and assess the preliminary anti-tumor activity of binimetinib administered in combination with nivolumab or nivolumab + ipilimumab in adult patients with advanced metastatic colorectal cancer (mCRC) with microsatellite stable (MSS) disease and presence of a RAS mutation that have received at least one prior line of therapy and no more than 2 prior lines of therapy. The study contains a Phase 1b period to determine the maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D) and schedule of binimetinib followed by a randomized Phase 2 period to assess the efficacy of the combinations.

DISEASE(S): Metastatic Colorectal Cancer,Microsatellite-stable (mss) Metastatic Colorectal Cancer With Ras Mutation,Ras-mutant Colorectal Cancer,Colorectal Neoplasms,Mss,Cancer

PROVIDER: 2253431 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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