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5-FU Based Maintenance Therapy in RAS Wild Type Metastatic Colorectal Cancer After Induction With FOLFOX Plus Panitumumab

ABSTRACT: This randomized trial studies how well panitumumab, leucovorin calcium, and fluorouracil after combination chemotherapy and panitumumab induction work in treating patients with RAS wild type colorectal cancer that has spread from where it started to nearby tissue or lymph nodes or other places in the body or cannot be removed by surgery. Monoclonal antibodies, such as panitumumab, may interfere with the ability of tumor cells to grow and spread. Drugs used in chemotherapy, such as leucovorin calcium, fluorouracil, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving panitumumab, leucovorin calcium, and fluorouracil after combination chemotherapy and panitumumab induction may work better in treating patients with colorectal cancer.

DISEASE(S): Stage Iva Colorectal Cancer Ajcc V7,Stage Iv Colorectal Cancer Ajcc V7,Colorectal Adenocarcinoma,Stage Ivb Colorectal Cancer Ajcc V7,Colorectal Neoplasms,Stage Iii Colorectal Cancer Ajcc V7,Ras Wild Type,Stage Iiic Colorectal Cancer Ajcc V7,Stage Iiib Colorectal Cancer Ajcc V7,Stage Iiia Colorectal Cancer Ajcc V7

PROVIDER: 2255700 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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