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S1613, Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients With Locally Advanced or Metastatic HER2/Neu Amplified Colorectal Cancer That Cannot Be Removed by Surgery

ABSTRACT: This randomized phase II trial studies how well trastuzumab and pertuzumab work compared to cetuximab and irinotecan hydrochloride in treating patients with HER2/neu amplified colorectal cancer that has spread from where it started to other places in the body and cannot be removed by surgery. Monoclonal antibodies, such as trastuzumab and pertuzumab, may interfere with the ability of tumor cells to grow and spread. Drugs used in chemotherapy, such as cetuximab and irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving trastuzumab and pertuzumab may work better compared to cetuximab and irinotecan hydrochloride in treating patients with colorectal cancer.

DISEASE(S): Adenocarcinoma,Stage Ivb Rectal Cancer Ajcc V7,Carcinoma,Stage Iiib Colon Cancer Ajcc V7,Recurrent Colon Carcinoma,Stage Iiia Colon Cancer Ajcc V7,Stage Iv Rectal Cancer Ajcc V7,Erbb2 Gene Amplification,Stage Iii Colon Cancer Ajcc V7,Stage Iiia Rectal Cancer Ajcc V7,Stage Iiic Rectal Cancer Ajcc V7,Rectal Adenocarcinoma,Recurrent Rectal Carcinoma,Stage Ivb Colon Cancer Ajcc V7,Rectal Neoplasms,Stage Iv Colon Cancer Ajcc V7,Stage Iva Rectal Cancer Ajcc V7,Stage Iva Colon Cancer Ajcc V7,Stage Iii Rectal Cancer Ajcc V7,Colon Adenocarcinoma,Stage Iiib Rectal Cancer Ajcc V7,Colonic Neoplasms,Stage Iiic Colon Cancer Ajcc V7

PROVIDER: 2260710 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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