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TAS102 in Combination With NAL-IRI in Advanced GI Cancers

ABSTRACT: This phase I/II trial studies the best dose and how well trifluridine/tipiracil hydrochloride combination agent TAS-102 (TAS-102) and nanoliposomal irinotecan work in treating patients with gastrointestinal cancers that have spread to other places in the body (metastatic) or cannot be removed by surgery. Drugs used in the chemotherapy, such as trifluridine/tipiracil hydrochloride combination agent TAS-102 and nanoliposomal irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.

DISEASE(S): Adenocarcinoma,Colorectal Adenocarcinoma,Unresectable Digestive System Adenocarcinoma,Gastric Adenocarcinoma,Stage Iv Gastric Cancer,Stage Iii Pancreatic Cancer,Stage Iii Colorectal Cancer,Stage Iv Colorectal Cancer,Stage Iv Pancreatic Cancer,Unresectable Pancreatic Carcinoma,Metastatic Pancreatic Adenocarcinoma,Stage Iva Colorectal Cancer,Non-resectable Cholangiocarcinoma,Colorectal Neoplasms,Stage Ivb Colorectal Cancer,Pancreatic Neoplasms,Stomach Neoplasms,Stage Iii Gastric Cancer,Cholangiocarcinoma

PROVIDER: 2260946 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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