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Guadecitabine and Nivolumab in Treating Refractory Metastatic Colorectal Cancer

ABSTRACT: This phase Ib/II trial studies the side effects and best dose of guadecitabine when given together with nivolumab and to see how well they work in treating participants with colorectal cancer that does not respond to treatment and has spread to other places in the body. Drugs used in chemotherapy, such as guadecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as nivolumab, may interfere with the ability of tumor cells to grow and spread. Giving guadecitabine and nivolumab may work better in treating participants with colorectal cancer.

DISEASE(S): Stage Ivb Colorectal Cancer Ajcc V8,Stage Ivc Colorectal Cancer Ajcc V8,Cpg Island Methylator Phenotype,Stage Iva Colorectal Cancer Ajcc V8,Colorectal Adenocarcinoma,Stage Iv Colorectal Cancer Ajcc V8,Carcinoma,Colorectal Neoplasms,Metastatic Microsatellite Stable Colorectal Carcinoma,Refractory Colorectal Carcinoma

PROVIDER: 2276905 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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