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Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer

ABSTRACT: The performance of SGM-101, an intraoperative imaging agent, will be compared to that of standard "white light" visualization during surgical resections of colorectal cancer.

DISEASE(S): Patients Undergoing Curative Surgery For Colorectal Cancer,Colorectal Cancer Stage Iv,Colorectal Cancer Recurrent,Colorectal Neoplasms,Colorectal Cancer Metastatic,Cancer,Colorectal Cancer Stage Iii

PROVIDER: 2283240 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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SGM-101 in Colorectal Brain Metastases.

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RNA-seq BHT-101 cells and BHT-101 ASH1L KO cell lines

Project description:The goal of this study is to assess the role of ASH1 like histone lysine methyltransferase (ASH1L) in the biology of anaplastic thyroid cancer. CRISPR-Cas9 was used to create 4 independent cell lines derived from BHT-101 anaplastic thyroid cancer cells with premature stop codons prior to the catalytic domain within both alleles of ASH1L. RNA-seq was performed on these 4 KO cell lines, and compared to 3 biological replicates of wild type BHT-101 cells.

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ChIP-seq BHT-101 cells and BHT-101 ASH1L KO cell lines

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