Effectiveness Assessment of Riluzole in the Prevention of Oxaliplatin-induced Peripheral Neuropathy.

ABSTRACT: It is a phase II trial, randomized, parallel, double blind, multicenter, comparing riluzole versus placebo. The trial population is composed of patients ≥18 years old that have developed stage II/III colorectal cancer and are eligible for Simplified FOLFOX4 (6-12 cycles) adjuvant chemotherapy. The primary objective is to assess the preventive efficacy of riluzole on the severity of oxaliplatin-induced peripheral neuropathy during the Simplified FOLFOX4 adjuvant chemotherapy of stage II/III colorectal cancers.

DISEASE(S): Peripheral Nervous System Diseases,Colorectal Cancer Stage Ii/iii With Adjuvant Oxaliplatin-based Chemotherapy (simplified Folfox4),Colorectal Cancer,Oxaliplatin-induced Peripheral Neuropathy

PROVIDER: 2288100 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR