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Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers

ABSTRACT: This is a Phase 2 study to evaluate the efficacy of a non-myeloablative lymphodepleting preparative regimen followed by infusion of autologous TIL and high-dose aldesleukin in patients with locally advanced, recurrent, or metastatic cancer associated with one of the following cancer types: 1.) gastric/esophagogastric, 2.) colorectal, 3.) pancreatic, 4.) sarcoma, 5.) mesothelioma, 6.) neuroendocrine, 7.) squamous cell cancer, 8.) Merkle cell, 9.) mismatch repair deficient and/or microsatellite unstable cancers, and 10.) patients who have exhausted conventional systemic therapy options by using the objective response rate (ORR).

DISEASE(S): Neuroendocrine Tumors,Microsatellite Instability,Sarcoma,Colorectal Cancer,Mesothelioma,Mismatch Repair Deficiency,Pancreatic Cancer,Merkel Cell Carcinoma,Carcinoma, Merkel Cell,Neoplasms, Squamous Cell,Carcinoma, Squamous Cell,Squamous Cell Cancer,Gastric Cancer

PROVIDER: 2304475 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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