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Basket Trial for Combination Therapy With Durvalumab (Anti-PDL1) (MEDI4736) and Tremelimumab (Anti-CTLA4) in Patients With Metastatic Solid Tumors

ABSTRACT: To determine the efficacy (as measured by overall tumour response rate) of the combination of durvalumab and tremelimumab when given to previously treated patients with solid tumors harboring a high mutational load.

DISEASE(S): Stomach Adenocarcinoma,Adenocarcinoma,Squamous Cell Carcinoma Of Head And Neck,Colorectal Adenocarcinoma,Metastatic Colorectal Cancer,Adenocarcinoma Of The Gastrooesophageal Junction,Prostate Adenocarcinoma,Triple Negative Breast Neoplasms,Esophageal Adenocarcinoma,Prostate Cancer,Triple Negative Breast Cancer,Metastatic Colorectal Adenocarcinoma (without Microsatellite Instability (not Msi)), Triple Negative Breast Cancer, Prostate Adenocarcinoma, Stomach And Esophageal Gastric Junction Adenocarcinoma And Human Papilloma Virus (hpv) Negative Head And Neck Squamous Cell Carcinoma With Detection Of ≥ 5 Somatic Mutations Per Megabase Measured By Whole Exome Sequencing In A Tumor Sample Of The Patient

PROVIDER: 2308027 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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