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Ramucirumab and Paclitaxel or FOLFIRI in Advanced Small Bowel Cancers

ABSTRACT: This phase II trial studies how well ramucirumab and paclitaxel or the FOLFIRI regimen (leucovorin calcium, fluorouracil, and irinotecan hydrochloride) work in treating patients with small bowel cancers that have spread extensively to other anatomic sites (advanced) or are no longer responding to treatment (refractory). Ramucirumab is a monoclonal antibody that attaches to and inhibits a molecule called VEGFR-2. This may restrain new blood vessel formation therefore reducing nutrient supply to tumor which may interfere with tumor cell growth and expansion. Drugs used in chemotherapy, such as paclitaxel, leucovorin calcium, fluorouracil, and irinotecan hydrochloride work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving Ramucirumab plus paclitaxel or FOLFIRI, may be helpful in treating advanced or refractory small bowel cancers and may help patients live longer.

DISEASE(S): Adenocarcinoma,Metastatic Small Intestinal Adenocarcinoma,Stage Iiib Small Intestinal Adenocarcinoma Ajcc V8,Stage Iv Small Intestinal Adenocarcinoma Ajcc V8,Stage Iiia Small Intestinal Adenocarcinoma Ajcc V8,Stage Iii Small Intestinal Adenocarcinoma Ajcc V8

PROVIDER: 2325221 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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