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Study of Trametinib and Ruxolitinib in Colorectal Cancer and Pancreatic Adenocarcinoma

ABSTRACT: The purpose of this research study to find out if the drug trametinib in combination with ruxolitinib is safe, tolerable and has beneficial effects in people who has certain type of cancers including the type that you have. Patients with RAS mutant colorectal cancer and pancreatic adenocarcinoma are invited to participate in this study. This is the first time that both trametinib and ruxolitinib are studied in combination. Trametinib is marketed in several countries with the brand name Mekinist for the treatment of melanoma (a type of skin cancer). Trametinib has been studied extensively in cancer and has been tested in many patients. Ruxolitinib is an oral inhibitor of JAK1 and JAK2 tyrosine kinases and is approved for treatment of adult polycythemia vera and myelofibrosis. Ruxolitinib has been studied extensively in many patients.

DISEASE(S): Adenocarcinoma,Pancreatic Adenocarcinoma,Colorectal Cancer,Colorectal Neoplasms

PROVIDER: 2332707 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Acute and chronic treatment of trametinib plus lapatinib in patient-derived xenografts (PDX) of pancreatic adenocarcinoma (PDAC)

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