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Regorafenib, Ipilimumab and Nivolumab for the Treatment of Chemotherapy Resistant Microsatellite Stable Metastatic Colorectal Cancer

ABSTRACT: This phase I trial studies the side effects and best dose of regorafenib when given together with ipilimumab and nivolumab in treating patients with microsatellite stable colorectal cancer that has spread to other places in the body (metastatic) and remains despite chemotherapy treatment (resistant). Regorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as ipilimumab and nivolumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving regorafenib, ipilimumab and nivolumab may slow the tumor growth and/or shrink the tumor size in patients with colorectal cancer.

DISEASE(S): Adenocarcinoma,Metastatic Colorectal Adenocarcinoma,Stage Iva Colorectal Cancer Ajcc V8,Stage Ivb Rectal Cancer Ajcc V8,Stage Iiib Colon Cancer Ajcc V8,Metastatic Colorectal Carcinoma,Stage Iv Rectal Cancer Ajcc V8,Stage Iiic Rectal Cancer Ajcc V8,Stage Iii Colon Cancer Ajcc V8,Metastatic Colon Adenocarcinoma,Stage Ivc Rectal Cancer Ajcc V8,Stage Ivb Colorectal Cancer Ajcc V8,Stage Iv Colon Cancer Ajcc V8,Stage Iiib Rectal Cancer Ajcc V8,Stage Iiia Colon Cancer Ajcc V8,Colorectal Neoplasms,Stage Iva Colon Cancer Ajcc V8,Stage Ivc Colon Cancer Ajcc V8,Stage Iiic Colon Cancer Ajcc V8,Stage Ivc Colorectal Cancer Ajcc V8,Stage Iv Colorectal Cancer Ajcc V8,Advanced Colon Adenocarcinoma,Metastatic Rectal Adenocarcinoma,Stage Iiia Rectal Cancer Ajcc V8,Stage Ivb Colon Cancer Ajcc V8,Stage Iva Rectal Cancer Ajcc V8,Rectal Neoplasms,Stage Iii Rectal Cancer Ajcc V8,Colonic Neoplasms

PROVIDER: 2337271 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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