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Testing the Anti-cancer Drug, Rogaratinib (BAY 1163877), for Treatment of Advanced Sarcoma With Alteration in Fibroblast Growth Factor Receptor (FGFR 1-4), and in Patients With SDH-deficient Gastrointestinal Stromal Tumor (GIST)

ABSTRACT: This phase II trial studies the effect of rogaratinib in treating patients with sarcoma with a change in a group of proteins called fibroblast growth factor receptors (FGFRs) or SDH-deficient gastrointestinal stromal tumor (GIST). Rogaratinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

DISEASE(S): Stage Iii Small Intestinal, Esophageal, Colorectal, Mesenteric, And Peritoneal Gastrointestinal Stromal Tumor Ajcc V8,Stage Iv Gastric And Omental Gastrointestinal Stromal Tumor Ajcc V8,Locally Advanced Gastrointestinal Stromal Tumor,Sarcoma,Locally Advanced Sarcoma,Metastatic Sarcoma,Stage Iii Gastric And Omental Gastrointestinal Stromal Tumor Ajcc V8,Stage Iv Small Intestinal, Esophageal, Colorectal, Mesenteric, And Peritoneal Gastrointestinal Stromal Tumor Ajcc V8,Metastatic Gastrointestinal Stromal Tumor,Neoplasms,Gastrointestinal Stromal Tumors

PROVIDER: 2355161 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Expression Data from Gastrointestinal Stromal Tumor (GIST) Cell Lines

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GIST proteome dataset(Proteomic Maps of Human Gastrointestinal Stromal Tumor Subgroups)

Project description:Gastrointestinal stromal tumor (GIST) is a common sarcoma of gastrointestinal tract (GIT) with high metastatic and recurrence rates, but the proteomic features are still less understood. Here we performed systematic quantitative proteome profiling of GIST from 13 patients classified into very low/low, intermediate and high risk subgroups. An extended cohort of GIST (n = 131) was used for immunohistochemical validation of proteins of interest. In total, 10064 proteins were quantified, covering 61% of the GIT transcriptome from The Human Protein Altas. Out of the 10064 quantified proteins, 4938 proteins were observed in all 13 cases with 518 proteins upregulated and 190 proteins downregulated in tumorous tissues independent of risk rating. Pathway analysis showed that the downregulated proteins were mostly enriched in metabolic pathway, while the upregulated proteins mainly belonged to spliceosome pathway. In addition, 131 proteins showed differentially expressed patterns among GIST subgroups with statistical significance. The 13 GIST cases were classified into 3 subgroups perfectly based on the expression of these proteins. The molecular phenotypes of oncoproteins, tumor suppressors, phosphatase and kinases were summarized, and some important molecules were observed. Immunohistochemical analysis of two phosphatases PTPN1 (n = 117) and PPP2CB (n=113) revealed that the GIST patients with high PTPN1 had low chances of developing metastasis, and the expression of PPP2CB was likely to be associated with GIST risk. Collectively, this work provides valuable information for understanding the inherent biology and evolution of GIST.

2019-01-29 | PXD011299 | iProX

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