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Study to Test the Safety and Tolerability of PF-07209960 in Advanced or Metastatic Solid Tumors

ABSTRACT: This is a first-in-human, Phase 1, open label, multicenter, multiple dose, dose escalation and dose expansion study intended to evaluate the safety, pharmacokinetic, pharmacodynamic, and potential clinical benefit of PF-07209960, an anti-PD-1 targeting IL-15 fusion protein, in participants with selected locally advanced or metastatic solid tumors for whom no standard therapy is available, or would not be an appropriate option in the opinion of the participant and their treating physician, or participants who have refused standard therapy. The study contains 2 parts, single agent Dose Escalation (Part 1) to determine the recommended dose of PF-07209960, followed by Dose Expansion (Part 2) in selected tumor types at the recommended dose.

DISEASE(S): Colorectal Carcinoma,Squamous Cell Carcinoma Of Head And Neck,Carcinoma,Squamous Cell Carcinoma Of The Head And Neck,Ovarian Carcinoma,Advanced Solid Tumor,Carcinoma, Renal Cell,Colorectal Neoplasms,Urothelial Carcinoma,Non-small-cell Lung Cancer,Renal Cell Carcinoma

PROVIDER: 2357699 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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