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Binimetinib and Palbociclib Before Surgery for the Treatment of Operable KRAS-Positive Lung, Colorectal, or Pancreatic Cancer

ABSTRACT: This early phase I trial studies the direct effects on cancer cells of the drugs binimetinib and palbociclib, in patients with KRAS-positive lung, colorectal, or pancreatic cancer that can be removed by surgery (operable). Binimetinib and palbociclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving binimetinib and palbociclib may halt the growth of cancer cells and improve access of the immune system cells, a patient’s own cells that fight infection and cancer, into the tumor.

DISEASE(S): Colorectal Carcinoma,Lung Adenocarcinoma,Carcinoma,Malignant Solid Neoplasm,Colorectal Neoplasms,Adenocarcinoma Of Lung,Pancreatic Neoplasms,Pancreatic Carcinoma

PROVIDER: 2376238 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Binimetinib and Palbociclib or TAS-102 in Treating Patients With KRAS and NRAS Mutant Metastatic or Unresectable Colorectal Cancer

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