Prospective randomised clinical trial phase II: 5-fluorouracil/folinic acid (5-FU/FA) and irinotecan versus combination cepecitabin and irinotecan in patients with metastatic colorectal cancer as first line treatment

ABSTRACT: Study hypothesis: There will be no statistically significant differences in efficacy, safety and survival of XELIRI regimen compared to standard FOLFIRI regimen in neoadjuvant setting of patients with unresectable liver-only metastases of colorectal cancer. Primary outcome(s): During the therapy, the following were assessed at baseline, 3 and 6 months, thereafter follow-up was every 3 months until progression of the disease (no limit on the maximum duration of follow-up): 1. Response rate: Response Evaluation Criteria in Solid Tumors (RECIST) 2. Rate of radical surgical resection (R0 resection)

DISEASE(S): Inoperable Liver Metastases Of Colorectal Cancer

PROVIDER: 2413517 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR