Analysis and Comparison of the composition and metabolic function of the intestinal microbiome of tumor patients with and without tumor cachexia: a prospective, non-interventional, explorative cohort-study in patients with gastrointestinal tumor stage UICC III-IV

ABSTRACT: Interventions: Group 1: Arm 1: Blood-, urine- and stool-samples of 60 patients with gastrointestinal tumors (UICC III-IV) without tumor cachexia will be frozen. The samples will be collected and send to the analysis lab for analysis. In addition, a questionnaire will be completed by the patient. Group 2: Arm 2: Blood-, urine- and stool-samples of 60 patients with gastrointestinal tumors (UICC III-IV) with tumor cachexia will be frozen. The samples will be collected and send to the analysis lab for analysis. In addition, a questionnaire will be completed by the patient. Primary outcome(s): - Evaluation of intestinal genes in stool samples of patients using next-generation sequencing technology - Identification of differences regarding the diversity of intestinal microorganisms between both groups Primary and endpoint will be assessed once based on the collected samples. No follow-up samples will be collected. Study Design: Allocation: ; Masking: ; Control: ; Assignment: ; Study design purpose: basic science

DISEASE(S): Malignant Neoplasm, Primary Site Unspecified,Cachexia

PROVIDER: 2433991 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR