Liver Image Guided High Dose Radiation Therapy for the Treatment of Colorectal Liver Metastases

ABSTRACT: Interventions: Stereotactic Radiation; Six fractions of radiotherapy delivered with 2-3 fractions per week at least one fraction 24 hours apart per week with risk adjusted dosing based on mean liver dose; 1. 60Gy in 6# delivered over 2-3 weeks for mean liver dose < 13.3Gy 2. 51Gy in 6# delivered over 2-3 weeks for mean liver dose 13.3-15.0Gy 3. 42Gy in 6# delivered over 2-3 weeks for mean liver dose 15.1-17.5Gy Primary outcome(s): To determine that delivery of high dose stereotactic image guided radiotherapy for colo-rectal liver metastases can be performed in a multidisciplinary setting. Successful delivery of stereotactic image guided radiotherapy for liver cancer will be indicated by 0 major clinical violations and <4 minor clinical violations on the planning review. [3 months post treatment ] Study Design: Purpose: Treatment; Allocation: Non-randomised trial; Masking: Open (masking not used);Assignment: Single group;Type of endpoint: Safety

DISEASE(S): Liver Metastases From Colo-rectal Cancer,Cancer-bowel-back Passage (rectum) Or Large Bowel (colon)

PROVIDER: 2460056 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR