Assessing the Olympus 190 series narrow band imaging for colonic polyp detection rates: A prospective randomised multicentre study

ABSTRACT: Interventions: Participants are selected from patients already undergoing colonoscopy for various indications (Ie; family history of colorectal cancer, signs or symptoms concerning for bowel disease). The only intervention study participants are exposed to is a colonoscopy that they would undergo regardless of their involvement in the study. Patients undergo colonoscopy and are randomised prior to the procedure to either narrow band imaging or standard white light on Olympus 190 series colonoscopes. These are illumination settings on the colonoscope and can be used by a simple push of a button. Narrow band imaging uses filters to illuminate tissue at a selected wavelengths (415 and 540nm)- giving a high definition and excellent visual determination of polyp/adenoma histology. The proceduralist will be told prior to the procedure which modality they will be required to use and then they will complete the withdrawal of the colonoscope (when polyp detection is predominantly done) in this modality. The procedure will be performed by consultant gastroenterologists or advanced trainees under the direct supervision of consultants. Each procedure usually takes about 15 minutes and they will all be required to have a withdrawal time of at least 7 minutes (which is associated with a higher polyp and adenoma pick up rate). Primary outcome(s): adenoma detection rate- proportion of screening colonoscopies that detect 1 or more adenomas. This is will be done by reviewing colonoscopy reports and histology reports for all patients involved in the study.[after colonoscopy randomised to narrow band imaging or standard white light] Study Design: Purpose: Diagnosis; Allocation: Randomised controlled trial

DISEASE(S): Oral And Gastrointestinal-other Diseases Of The Mouth, Teeth, Oesophagus, Digestive System Including Liver And Colon,Cancer-bowel-back Passage (rectum) Or Large Bowel (colon),Colorectal Polyps/cancer

PROVIDER: 2463444 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR