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Infectious surgical site complications after oral antibiotic bowel preparation for minimally-invasive rectal cancer surgery

ABSTRACT: Interventions: Drug : 1. experimental group (A) - mechanical bowel preparation (PEG) + IV antibiotics 2. control group (B) - mechanical bowel preparation (PEG) + IV antibiotics + oral antibiotics (rifaximin + metronidazole) 3. pre-operative preparation 3.1. mechanical bowel preparation - PEG prefered - water only permitted on the day before operation 3.2. oral antibiotics - 14, 16, 22 hour the day before surgery - 400mg rifaximin + 500mg metronidazole 3.3. IV antibiotics - 2nd generation cephalosporin - venous injection within 30 minutes before surgery - additional dose is at the discretion of the operators Primary outcome(s): surgical site infection rate during first 30 days Primary Purpose : Prevention, Intervention Model : Factorial, Blinding/Masking : Open, Allocation : RCT

DISEASE(S): Neoplasms

PROVIDER: 2512754 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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