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Iron deficiency, platelets and thromboembolism in cancer patients

ABSTRACT: Primary objectives: To evaluate the effect of iron therapy on platelet counts in patients with colorectal cancer and iron deficiency Primary endpoints: drop in platelet counts>10%

DISEASE(S): Colorectal Cancer, Iron Deficiency,Colorectal Cancer,Iron Deficiency

PROVIDER: 2531118 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Transcription profiling of Arabidopsis roots after Iron deficiency

Project description:This SuperSeries is composed of the following subset Series:; GSE10496: Expression analysis of the effect of protoplasting and FACS sorting in roots exposed to iron deficiency (-Fe); GSE10497: Expression analysis of root developmental zones after iron deficiency (-Fe) treatment; GSE10501: Expression analysis of root cell-types after iron deficiency (-Fe) treatment; GSE10502: Time course expression analysis of the iron deficiency (-Fe) response in Arabidopsis roots Experiment Overall Design: Refer to individual Series

2008-06-11 | E-GEOD-10576 | biostudies-arrayexpress

Iron-Heme-Bach1 Axis Is Involved In Erythroblast Adaptation To Iron Deficiency

Project description:Iron plays the central role in the oxygen transport by the erythrocyte as a constituent of heme and hemoglobin. The importance of iron and heme also resides in their regulatory roles during erythroblast maturation. The transcription factor Bach1 may be involved in their regulatory roles since it is inactivated by direct binding of heme. To address whether Bach1 is involved in the responses of erythroblasts to iron status, low iron conditions that induced severe iron deficiency in mice were established. Under iron deficiency, extensive gene expression changes and mitophagy disorder were induced during maturation of erythroblasts. Bach1 mice showed more severe iron deficiency anemia in the developmental phase of mice and a retarded recovery once iron was replenished when compared with wild-type mice. In the absence of Bach1, the expression of globin genes and Hmox1 (encoding heme oxygenase-1) was de-repressed in erythroblasts under iron deficiency, suggesting that Bach1 represses these genes in erythroblasts under iron deficiency to balance the levels of heme and globin. Moreover, an increase in genome-wide DNA methylation was observed in erythroblasts of Bach1–/– mice under iron deficiency. These findings reveal the principle role of iron as a regulator of gene expression in erythroblast maturation and suggest that the iron-heme-Bach1 axis is important for a proper adaptation of erythroblast to iron deficiency to avoid toxic aggregates of non-heme globin.

2016-12-14 | GSE78955 | GEO

Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate.

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Iron Deficiency Triggered Transcriptome Changes in Bread Wheat

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2020-11-24 | GSE162027 | GEO

Usefulness of Fecal Immunochemical Test in Iron Deficiency Anemia (IDAFIT)

Project description:Prospective study to test whether the immunochemical fecal occult blood test (FIT) for colorectal cancer (CRC) helps to prioritize patients with iron deficiency anemia for colonoscopy.

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Arabidopsis root gene expression under iron deficiency in myb10myb72

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2013-09-05 | E-MEXP-3649 | biostudies-arrayexpress

Cardiac transcriptome in iron-deficiency anemia

Project description:Cardiac transcriptome in iron-deficiency anemia

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Cardiac transcriptome in iron-deficiency anemia

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2015-08-11 | PXD002126 | Pride

Genetic Model of iron deficiency in the Mouse Liver

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