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Temozolomide and irinotecan combination chemotherapy in patients with a specific subgroup of colorectal cancer and with circulating tumor DNA positivity after standard post-operative treatment

ABSTRACT: Primary objectives: To assess the activity in terms of seroreversion of temozolomide and irinotecan (TEMIRI) consolidation regimen administered to patients with high-risk stage II (pT4) or III microsatellite stable, MGMT silenced CRC and positive post-adjuvant ctDNA after standard oxaliplatin-based adjuvant chemotherapy. Primary endpoints: The activity of TEMIRI will be measured as the rate of patients with post-treatment seroreversion and disease-free at 2 years.

DISEASE(S): Carcinoma Colorettale In Stadio Ii (pt4)/iii In Con Positività Del Dna Tumorale Circolante Dopo Terapia Adiuvante Contenente Oxaliplatino.,Stage Ii (pt4)/iii Colorectal Cancer With Positive Circulating Tumor Dna (ctdna) After Oxaliplatin-based Adjuvant Chemotherapy,Adenocarcinoma Of Colon Stage Iii,Adenocarcinoma Of Colon Stage Ii

PROVIDER: 2540916 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Project description:Surgical resection is curative for 75% of stage II and 50% of stage III colon cancer patients. The magnitude of benefit of adjuvant chemotherapy in terms of disease-free (DFS) and overall survival (OS) varies according to TNM stage and microsatellite status. Standard adjuvant chemotherapy includes fluoropyrimidine and oxaliplatin regimens for up to six months. Circulating tumor DNA (ctDNA) detected after surgical resection reflects the presence of micrometastatic disease and pivotal observational studies addressed the prognostic value of ctDNA in the post-surgical setting. Adjuvant chemotherapy can promote the clearance of ctDNA, and ctDNA clearance after adjuvant chemotherapy is prognostic for better DFS in patients with stage III resected cancers and post-operative positive ctDNA. ctDNA may be investigated as a potential real-time surrogate biomarker of the efficacy of adjuvant therapy, but suggest that patients with ctDNA persistence after standard chemotherapy might be "molecularly metastatic" and may benefit from additional "consolidation" non-cross resistant strategies aimed at clearing micrometastatic disease. Temozolomide has modest but non-negligible activity (about 10%) in chemo-refractory patients with MGMT methylated mCRC. The response rate to temozolomide-based therapy in pretreated patients is increased to up to 20% when restricting the focus on those with MGMT IHC-negative/MGMT methylated and MSS cancers Significant activity (ORR 26%) and favorable safety profile were reported by the combination of temozolomide and irinotecan (TEMIRI regimen) in patients with pretreated MGMT methylated/MSS mCRC, thus suggesting that the two agents may have synergist activity in line with preclinical data. Based on all these considerations, there is a strong rationale for investigating TEMIRI regimen as consolidation non-cross resistant therapy in a liquid-biopsy driven interventional trial. Eligible patients with MGMT-silenced, MSS, radically resected CRC and detectable ctDNA after standard chemotherapy will be enrolled and will receive 6-month post-adjuvant/consolidation TEMIRI (given for up to 6 monthly cycles).

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Temozolomide and irinotecan combination chemotherapy in patients with a specific subgroup of colorectal cancer and with circulating tumor DNA positivity after standard post-operative treatment

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