Browse
Submit Data
Databases
API
Help

Dataset Information

3 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Outcome of Vitamin D supplementation alongwith the standard treatment in Lymphoma Patients.

ABSTRACT: Primary outcome(s): a)To study the association of baseline vitamin D level with Overall Response Rate(ORR) in patients with newly diagnosed lymphoma. b)To study the effect of vitamin D supplementation on Overall Response Rate (ORR) in the vitamin D deficient patients with newly diagnosed lymphoma. Timepoint: August 2018 to May 2020

DISEASE(S): Follicular Lymphoma Grade Ii,A- Cutaneous T-cell Lymphoma, Unspecified,Mature T/nk-cell Lymphomas, Unspecified,Angioimmunoblastic T-cell Lymphoma,Extranodal Marginal Zone B-cell Lymphoma Of Mucosa-associated Lymphoid Tissue [malt-lymphoma],Cutaneous Follicle Center Lymphoma,Follicular Lymphoma, Unspecified,Mixed Cellularity Hodgkin Lymphoma,Follicular Lymphoma Grade Iiib,Follicular Lymphoma Grade Iiia,Anaplastic Large Cell Lymphoma, Alk-positive,Malignant Immunoproliferative Disease, Unspecified,Malignant Neoplasm Of Lymphoid, Hematopoietic And Related Tissue, Unspecified,Mycosis Fungoides,Hodgkin Lymphoma, Unspecified,Follicular Lymphoma Grade Iii, Unspecified,Hepatosplenic T-cell Lymphoma,Blastic Nk-cell Lymphoma,Diffuse Follicle Center Lymphoma,Nodular Lymphocyte Predominant Hodgkin Lymp,Mediastinal (thymic) Large B-celllymphoma,Follicular Lymphoma Grade I,Lymphocyte Depleted Hodgkin Lymphoma,Burkitt Lymphoma,Diffuse Large B-cell Lymphoma,Enteropathy-type (intestinal) T-cell Lymphoma,Lymphoblastic (diffuse) Lymphoma,Anaplastic Large Cell Lymphoma, Alk-negative,Mantle Cell Lymphoma,Extranodal Nk/t-cell Lymphoma, Nasal Type,Lymphocyte-rich Hodgkin Lymphoma

PROVIDER: 2588839 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Discovery of novel differentially expressed genes related to interstitial fibrosis and tubular atrophy among kidney transplantation recipients by mRNA-sequencing

Project description:Interstitial fibrosis and tubular atrophy (IF/TA) after kidney transplantation causes chronic deterioration of graft function. IF/TA can be diagnosed by graft biopsy; however, non-invasive diagnostic methods are unavailable. In this study, we identified IF/TA-related differentially expressed genes (DEGs) through next-generation sequencing using peripheral blood mononuclear cells (PBMCs) PBMC samples from kidney transplantation recipients under standard immunosuppressive therapy (tacrolimus/mycophenolate mofetil or mycophenolate sodium/steroid) and diagnosed as IF/TA (n = 41) or normal (controls; n = 41) at their 1-year protocol biopsy were recruited between January 2020 and August 2020.

2023-08-30 | GSE218048 | GEO

Genetically-defined Diffuse Large B-cell Lymphoma Subsets Arise by Distinct Pathogenetic Mechanisms and Predicts Outcome

Project description:We obtained gene experssion profiles of 52 newly diagnosed diffuse large B-cell lymphoma (DLBCL).

2018-05-01 | GSE98588 | GEO

Transcription profiling of human pulmonary MALT lymphoma

Project description:Molecular pathways activated in MALT lymphoma are not well defined. In this study, we perform gene expression profiling on 35 pulmonary MALT lymphoma using fresh frozen biopsy samples Experiment Overall Design: Total RNA was extracted from fresh frozen tisues of 35 newly diagnosed Pulmonary MALT, as defined by WHO classification, and hybridized to Affymetrix U133plus2 chip. Gene expression profile from other B and T cell malignancies and normal cellular and tissue counterpart were obtained from published dataset for comparison.

2008-11-13 | E-GEOD-13314 | biostudies-arrayexpress

Effects of vitamin D supplementation on alveolar macrophage gene expression

Project description:The objective of the overall study was to determine the effects of oral vitamin D supplementation on alveolar macrophages from human subjects. In this substudy, subjects treated with vitamin D (intervention group) in paired analysis had small, but significant effects on immune-related differential gene expression pre versus post supplementation. In this study, we obtained alveolar macrophages by bronchoalveolar lavage of subjects before and after a 3 month vitamin D trial. RNA for the array was obtained shortly after bronchoscopy.

2014-04-08 | GSE56583 | GEO

Patients with Activated B-cell-like Diffuse Large B-cell Lymphoma (ABC DLBCL) in high and low infectious disease areas have different inflammatory gene signatures

Project description:DLBCL accounts for approximately 40% of newly diagnosed lymphomas worldwide. Several etiological mechanisms have been proposed. Among these are viral infections and chronic inflammation which may be associated with the initiation and progression of lymphoma.

2011-12-16 | GSE34339 | GEO

Effects of vitamin D supplementation on alveolar macrophage gene expression

2014-04-08 | E-GEOD-56583 | biostudies-arrayexpress

scRNA-seq and snucRNA-seq of human primary trophoblast organoids (PTO) and trophoblast stem cells (TSCs) differentiation into extravillous trophoblast organoids (EVTs)

Project description:This study aims to compare in vivo human trophoblast differentiation into EVTs to different in vitro trophoblast organoids using single-cell and single-nuclei RNA sequencing. The study includes two type of systems: human primary trophoblast organoids (PTO) and trophoblast stem cells (TSCs). Trophoblast stem cell (TSC) lines BTS5 and BTS11 derived by Okae and colleagues were grown as described previously (Okae et al. 2018) and together with EVT media. Primary trophoblast organoids (PTO) were grown and differentiated into EVT as previously described by Turco & Sheridan (Turco et al 2018; Sheridan et al 2020). This study shows that the main regulatory programs mediating EVT invasion in vivo are preserved in in vitro models of EVT differentiation from primary trophoblast organoids and trophoblast stem cells.

2023-02-09 | E-MTAB-12650 | biostudies-arrayexpress

Transcriptomics changes in liver metastatic biopsies of colorectal carcinoma between pre-treated and acquired resistance to Cetuximab [miRNA]

Project description:Two patients who were newly diagnosed and pathologically confirmed metastatic colorectal cancer were screened for eligibility between August 2011 and December 2013 in Affiliated Hospital, Academy of Military Medical Sciences. They were treated with Cetuximab in combination with FOLFOX regimen and obtained continuous partial responses in more than six months. CT scans of liver lesions were performed every two to eight weeks. The four biopsies were evaluated by two pathologists and were confirmed that the tumor purities were greater than 50%. Each biopsy was subjected to high-throughput RNA and small RNA sequencing to obtain expression profiles of genes and miRNAs.

2019-06-20 | GSE84269 | GEO

Transcriptomics changes in liver metastatic biopsies of colorectal carcinoma between pre-treated and acquired resistance to Cetuximab [mRNA]

2019-06-20 | GSE84267 | GEO

Influence of Vitamin D on Genome-Wide Expression in Natural Killer Cells

Project description:Vitamin D deficiency has been associated with decreased overall survival in patients with diffuse large B-cell lymphoma treated with rituximab. Natural killer cell-mediated antibody-dependent cytotoxicity is one of the main mechanisms of action of rituximab, and it has been shown to be enhanced after in vivo vitamin D supplementation. We aimed to explore molecular mechanisms behind these findings using whole transcriptome analysis of natural killer cells after vitamin D supplementation

2023-08-30 | GSE239308 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data