Project description:Interventions: Genomic test CANCERPLEX-JP OncoGuide NCC oncopanel system FndationONe CDx genome profile GUARDANT360 MSI Analysis System BRACAnalysis Primary outcome(s): Development of genome database Study Design: Single arm Non-randomized

| 2643590 | ecrin-mdr-crc

Genome-wide microRNA expression status of non-B non-C hepatocellular carcinoma assessed by 3D-Gene Human miRNA Oligo Chip (Toray, Japan)

Project description:Genome-wide microRNA expression analysis for clinical samples from patients in whom non-B non-C hepatocellular carcinoma developed. A pair of tissues (N=24 pairs) from non-tumor background and tumor was provided from every patient. A platform for this experiment was 3D-Gene Human miRNA Oligo Chip (Toray, Japan).

2017-03-31 | E-MTAB-4170 | biostudies-arrayexpress

Whole genome tiling path array CGH analysis of segmental copy number alterations in cervical cancer cells

Project description:Cervical cancer is the second most common malignancy in women worldwide, with high risk subtypes of human papillomavirus (HPV) constituting the major etiological agent. However, only a small percentage of women infected by the virus develop disease suggesting that additional host genetic alterations are necessary for disease progression. In this study we examined the genomes of a panel of commonly used model cervical cancer cell lines using a recently developed whole genome tiling path array for CGH analysis. Detailed analysis of genomic profiles enabled the detection of many novel aberrations which may have been missed by conventional cytogenetic methods. In total, 27 minimal regions of recurrent copy number alteration were identified that are potentially involved in tumorigenesis. Interestingly, fine mapping of the 3q gain, which is associated with the progression of precursor lesions to invasive cervical cancer, identified a minimal region of alteration harboring genes distinct from previous candidates. Novel regions of gene amplification, including the co-amplification of both the Birc and MMP gene clusters on 11q22, were also evident. Lastly, characterization of genomic structure at sites of HPV integration identified the copy number gain of host cellular sequences between the viral-host genomic boundaries in both SiHa and SW756, suggesting a direct role for HPV integration in the development of genetic abnormalities that initiate cervical cancer. This work represents the highest resolution look at a cervical cancer genome to date and offers definitive characterization of the alteration status of these cancer genomes. Whole genome tiling path array CGH profiles of 8 Cervical Cancer Cell Lines

2010-07-01 | E-GEOD-5049 | biostudies-arrayexpress

Diagnostic Reference Levels for Fluoroscopy-guided Gastrointestinal Procedures in Japan from the REX-GI Study: A Nationwide Multicentre Prospective Observational Study.

Project description: Not available

| S-EPMC8749231 | biostudies-literature