Browse
Submit Data
Databases
API
Help

Dataset Information

3 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Efficacy of line-assisted complete closure of large colorectal mucosal defects after endoscopic submucosal dissection: a randomized controlled trial

ABSTRACT: Interventions: Non-closure group Line-assisted complete closure group Primary outcome(s): Proportion of post-ESD coagulation syndrome Study Design: Parallel Randomized

DISEASE(S): Colorectal Neoplasm

PROVIDER: 2638363 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Efficacy of complete clip closure of the mucosal defect after colorectal-ESD : A randomized controlled, multicenter trial (CCC trial)

Project description:Interventions: without clip closure after ESD complete clip closure after ESD Primary outcome(s): Delayed adverse event rates (Post-ESD coagulation syndrome, delayed bleeding, delayed perforation), intention to treat analysis Study Design: Parallel Randomized

| 2654643 | ecrin-mdr-crc

A prospective study investigating the efficacy and safety of traction-band-assisted endoscopic closure for mucosal defect after colorectal endoscopic submucosal dissection: A multi-center trial (TBEC Trial)

Project description:Interventions: Traction-band-assisted endoscopic closure (TBEC) for mucosal defect after colorectal ESD Primary outcome(s): Complete closure of mucosal defect Study Design: Single arm Non-randomized

| 2740973 | ecrin-mdr-crc

Clip on Clip Closure Method (CCCM) for mucosal defect after colorectal endoscopic submucosal dissection: a prospective study

Project description:Interventions: For mucosal defect after ESD, only conventional clips are used and closed using Clip on Clip Closure Method. Primary outcome(s): Evaluate whether mucosal defect after ESD is closed by Clip on Clip Closure Method using conventional clip. Study Design: Single arm Non-randomized

| 2646572 | ecrin-mdr-crc

Efficacy of closure with clips of endoscopic submucosal dissection-induced colorectal ulcer: a randomized controlled trial

Project description:Interventions: 1:closure artificial ulcers after colorectal ESD;2:no-closure artificial ulcers after colorectal ESD Primary outcome(s): Reduction in area of ulcer Study Design: Non randomized control

| 2680879 | ecrin-mdr-crc

A multicenter prospective study of the efficacy of prophylactic clip closure for prevention of delayed bleeding after colorectal ESD (endoscopic submucosal dissection)

Project description:Interventions: Prophylactic clip closure after colorectal ESD Primary outcome(s): The rate of delayed bleeding after prophylactic clip closure Study Design: Single arm Non-randomized

| 2651772 | ecrin-mdr-crc

Neural tube closure defect

Project description:Neural tube closure defect

| PRJNA704672 | ENA

Efficacy of traction assisted endoscopic submucosal dissection using clip and line for colorectal neoplasms: a randomized controlled trial

Project description:Interventions: Conventional ESD group Traction assisted ESD group Primary outcome(s): ESD procedure time which is measured from the start of the submucosal injection until removal of the lesion Study Design: Parallel Randomized

| 2633910 | ecrin-mdr-crc

Transcriptional evaluation of the ductus arteriosus at the single cell level uncovers a requirement for vimentin for complete closure

Project description:Failure to close the ductus arteriosus immediately post-birth, patent ductus arteriosus (PDA), accounts for up to 10% of all congenital heart defects. Despite significant advances in PDA management options, including pharmacological treatment targeting the prostaglandin pathway, a proportion of patients fail to respond and must undergo surgical intervention. Thus, further refinement of the cellular and molecular mechanisms that govern vascular remodeling of this vessel is required. As anticipated, single-cell RNA sequencing on the ductus arteriosus in mouse embryos at E18.5, P0.5, and P5, revealed broad transcriptional alterations in the endothelial, smooth muscle, and fibroblast cell compartments. After close evaluation of the transcriptomic dataset, we predicted that vimentin might be required for complete closure of the vessel. Subsequent studies demonstrated that, in fact, mice with genetic deletion of vimentin fail to fully remodel the ductus arteriosus. Through single-cell RNA-sequencing and by tracking closure of the ductus arteriosus postnatally in mice, we uncovered the unexpected contribution of vimentin in driving complete closure of the ductus arteriosus potentially through regulation of the Notch signaling pathway.

2022-09-26 | GSE188202 | GEO

Efficacy and safety of a novel closure method Loop9 for mucosal defect after Colorectal Endoscopic submucosal dissection

Project description:Primary outcome(s): Complete closure rate

| 2724313 | ecrin-mdr-crc

Transcriptome profiling at neural tube closure site

Project description:Maternal diabetes is a teratogen that can lead to neural tube closure defects in the offspring. We therefore sought to compare gene expression profiles at the site of neural tube closure between stage-matched embryos from normal dams, and embryos from diabetic dams. Neurulation-stage mouse embryos at 8.5 days of gestation were used to prepare neural tissue at the anterior aspect of neural tube closure site 1. Tissue was procured from the open neural tube immediately anterior of the closure site, and from the closed neural tube immediately posterior to the closure site by laser microdissection. For each sample, 10 sections were pooled, total RNA was extracted, and 7 ng of total RNA were used for expression profiling by Tag sequencing using an Applied Biosystems SolidSAGE kit for library construction, and an AB SOLiD 5500 XL instrument for sequencing. Sequence reads were mapped to RefSeq RNA, and count data per gene were obtained using a modified version of the Applied Biosystems SOLiDâ?¢ SAGEâ?¢ Analysis Software. diabetic dam - closed neural tube // diabetic dam - open neural tube // normal dam - closed neural tube // normal dam - open neural tube

2016-10-24 | E-GEOD-41876 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data