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Usefulness of forward-viewing radial-array endoscopic ultrasonography for evaluating invasion depth of colorectal neoplasms

ABSTRACT: Interventions: We diagnose the invasion depth by pit pattern and EUS in the same group. Primary outcome(s): The accuracy for invasion depth of colorectal neoplasms Study Design: Single arm Non-randomized

DISEASE(S): Colorectal Neoplasms

PROVIDER: 2643268 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Magnifying chromoscopic colonoscopy versus endoscopic ultrasonography to predict depth of invasion for early colorectal cancer

Project description:Interventions: "A group: MC followed by EUS" for diagnosis of invasion depth From February 2011 to December 2013 "B group: EUS followed by MC" for diagnosis of invasion depth From February 2011 to December 2013 Primary outcome(s): Accuracy rate for invasion depth of early colorectal cancer by MC and EUS Study Design: Cross-over Randomized

| 2620527 | ecrin-mdr-crc

Chromoendoscopy using the non-extension sign as a marker is comparable to endoscopic ultrasonography in terms of diagnostic performance for evaluating the invasion depth of early colorectal cancer

Project description:Primary outcome(s): To compare diagnostic performance (sensitivity, specificity, and accuracy) for evaluating the invasion depth of T1b cancer between CE using the NES as a marker and EUS.

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The retrospective study to examine the usefulness of IMP3 immunostaining for tissue diagnosis and the diagnosis of invasion depth in colorectal neoplasm

Project description:Primary outcome(s): Tissue diagnostic accuracy rate and invasion depth accuracy rate of IMP3 immunostaining

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Comparison of diagnostic accuracy with narrow band imaging colonoscopy and endoscopic ultrasound for differentiation of submucosal invasive colorectal cancer

Project description:Interventions: Procedure/Surgery : To perform and compare the accuracy of both NBI and EUS at of colorectal cancer of subject Primary outcome(s): accuracy of assessment of NBI and EUS for depth of submucosal invasion

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Observation of Microvessels and Invasion in Early Colorectal Lesions by NBI

Project description:Combined with magnifying endoscopy,narrow-band imaging (NBI) contrasts microvascular architecture on lesion surface.The histology of early colorectal lesions could be predicted under NBI view.However,its capability for estimating invasion depth remains to be verified.The study is based on the hypothesis:NBI can predict histology and invasion depth,combined with the verification of microvessel count and MMP-7 expression.

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Establishment and Verification of Endoscopic Prediction Model for the Nature and Depth of Invasion of Colorectal Tumors and Exploration of New Diagnostic Methods

Project description:Interventions: Gold Standard:Definite diagnosis by pathology;Index test:Endoscopic Prediction Model for the Nature and Depth of Invasion of Colorectal Tumors and Exploration. Primary outcome(s): Endoscopic characteristics;SEN, SPE, ACC, AUC of ROC Study Design: Sequential

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Endoscopic Ultrasonography Miniature Probe Performance for Depth Diagnosis of Early Gastric Cancer with Suspected Submucosal Invasion.

Project description: Not available

| S-EPMC7492497 | biostudies-literature

Placental Accreta Spectrum: Upregulated Cytotrophoblast DOCK4 Contributes to Over Invasion

Project description:In humans, a subset of placental cytotrophoblasts (CTBs) invades the uterus and its vasculature, anchoring the pregnancy and ensuring adequate blood flow to the fetus. Appropriate depth is critical. Shallow invasion increases the risk of pregnancy complications, e.g., severe preeclampsia. Overly deep invasion, the hallmark of placenta accreta spectrum (PAS), increases the risk of pre-term delivery, hemorrhage and death. Previously a rare condition, the incidence of PAS has increased to 1:731 pregnancies, likely due to the rise in uterine surgeries (e.g., Cesarean sections). CTBs track along the scars deep into the myometrium and beyond. Here we compared the global gene expression patterns of CTBs from PAS cases to gestational age-matched control cells that invaded to the normal depth from preterm birth (PTB) deliveries. The mRNA encoding the guanine nucleotide exchange factor, DOCK4, mutations of which promote cancer cell invasion and angiogenesis, was the most highly differentially expressed molecule in PAS samples. Over-expression of DOCK4 increased CTB invasiveness, consistent with the PAS phenotype. Also, this analysis identified other genes with significantly altered expression in this disorder, potential biomarkers. These data suggest that CTBs from PAS cases up regulate a cancer-like pro-invasion mechanism, suggesting molecular as well as phenotypic similarities in the two pathologies.

2019-09-30 | GSE136048 | GEO

Pit-1 overexpression in the human breast adenocarcinoma MCF-7 cell line

Project description:The aim of the study is to evaluate Pit-1-induced genes in the MCF-7 cell line The Pit-1 transcription factor (also known as POU1F1) plays a critical role in cell differentiation during organogenesis of the anterior pituitary in mammals and is a transcriptional activator for pituitary gene transcription. Increased expression of Pit-1 has been reported in human tumorigenic breast cells. Here, we found that Pit-1 overexpression or knockdown in human breast cancer cell lines induced profound phenotypic changes in the expression of proteins involved in cell proliferation, apoptosis, and invasion. In immunodeficient mice, Pit-1 overexpression induced tumoral growth and promoted metastasis in lung. In patients with invasive ductal carcinoma of the breast and node-positive tumors elevated expression of Pit-1 was significantly and independently associated with the occurrence of distant metastasis. These findings suggest that Pit-1 could help to make a more accurate prognosis in patients with node positive breast cancer and may represent a new therapeutic target (Journal of Clinical Investigation 2010, 120:4289-4302)

2014-12-12 | GSE64101 | GEO

The safe and efficacy of forward viewing EUS for colorectal tumor

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