Browse
Submit Data
Databases
API
Help

Dataset Information

11 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 1

TR study of ‘A multicenter phase II study of eribulin monotherapy in patients with BRAF V600E mutant metastatic colorectal cancer (BRAVERY study)"

ABSTRACT: Primary outcome(s): cancer-related gene alteration, gene expression, microsatellite instability, BRAF mutant allele frequency

DISEASE(S): Braf V600e Mutant Metastatic Colorectal Cancer

PROVIDER: 2646701 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

TR study of ‘multicenter Phase II study to evaluate efficacy and safety of combination therapy with trastuzumab and pertuzumab in patients with HER2-positive metastatic colorectal cancer&quot

Project description:Primary outcome(s): Cancer-related gene alteration, expression of protein, and expression of RNA

| 2645675 | ecrin-mdr-crc

TR study of ‘A multi-center proof-of-concept phase2 study of encorafenib + binimetinib + cetuximab in patients with BRAF non-V600E mutated metastatic colorectal cancer (BIGBANG study)&quot

Project description:Primary outcome(s): Cancer related genome analysis, gene expression and molecular characterization analysis

| 2647002 | ecrin-mdr-crc

Dabrafenib plus trametinib versus dabrafenib monotherapy in patients with metastatic BRAF V600E/K-mutant melanoma: long-term survival and safety analysis of a phase 3 study.

Project description: Not available

| S-EPMC5834102 | biostudies-literature

Epigenetic alterations of a DNMT3B-mutant ICF patient at base-pair resolution

Project description:The immunodeficiency, centromere instability and facial anomalies (ICF) syndrome is associated with mutation of the DNA methyl-transferase DNMT3B, resulting in a reduction of enzyme activity. Aberrant expression of immune system genes and hypomethylation of pericentromeric regions accompanied by chromosomal instability were determined as alterations driving the disease phenotype. However, so far only technologies capable of analyzing single loci were applied to determine epigenetic alterations in ICF patients. In the current study, we performed whole-genome bisulphite sequencing to assess alteration in DNA methylation at base-pair resolution. Whole-genome bisulphite sequencing was performed to assess alteration in DNA methylation of one ICF patient and one healthy control sample at base-pair resolution.

2012-04-25 | E-GEOD-37578 | biostudies-arrayexpress

Epigenetic alterations of a DNMT3B-mutant ICF patient at base-pair resolution

2012-04-26 | GSE37578 | GEO

Evaluation of RAS gene status in circulating tumor DNA for colorectal cancer patients with RASg gene mutation

Project description:Primary outcome(s): the allele frequency of RAS gene mutation in circulating tumor DNA

| 2653459 | ecrin-mdr-crc

Targeted Disruption of V600E-Mutant BRAF Gene by CRISPR-Cpf1.

Project description: Not available

| S-EPMC5542387 | biostudies-literature

Functional characterization of a PROTAC directed against BRAF mutant V600E.

Project description: Not available

| S-EPMC7862923 | biostudies-literature

A poilot study of eribulin monotherapy in chemorefractory patients with BRAF V600E-mutant metastatic colorectal cancer

Project description:Interventions: Eribulin 1.4 mg/m2 days 1 and 8 (repeated every 21 days) Primary outcome(s): Objective response rate; ORR Study Design: Single arm Non-randomized

| 2642859 | ecrin-mdr-crc

Low-dose vemurafenib monotherapy in <i>BRAF<sup>V600E</sup></i> -mutated Erdheim-Chester disease.

Project description: Not available

| S-EPMC8023000 | biostudies-literature