Browse
Submit Data
Databases
API
Help

Dataset Information

3 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Evaluation of the clinical efficacy and the safety of minimally invasive radical surgical resection of colorectal cancer.

ABSTRACT: Interventions: A:small incision open radical operation on colo-rectal carcinoma;B:standard incision open radical operation on colo-rectal carcinoma Primary outcome(s): recovery conditions of intestinal function after operation;operation time;blood loss;hospitalization time;postoperative complication;recovery conditions of anal function after operation Study Design: Non randomized control

DISEASE(S): Colorectal Cancer

PROVIDER: 2672968 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Expression data collected using a custom Affymetrix array (Adenoma Biomarker Gene Chip) designed to differentiate neoplastic colorectal from non-neoplastic

Project description:This array was designed to verify a number of previously identified markers for colo-rectal adenoma. It contains probesets from the Affymetrix Hu133, HuGene and other novel probesets not included on other arrays. 68 samples of colon tissues were analysed, covering the classes normal, adenoma and carcinoma.

2010-11-13 | E-GEOD-24713 | biostudies-arrayexpress

Expression data collected using a custom Affymetrix array (Adenoma Biomarker Gene Chip) designed to differentiate neoplastic colorectal from non-neoplastic

2010-11-13 | GSE24713 | GEO

Comparison of NOSES and Conventional Laparoscopic Surgery in Colorectal Cancer

Project description:Radical surgery for rectal cancer has evolved from the initial concept of total mesorctal excision (TME) to the wide application of laparoscopic surgery in the radical treatment of rectal cancer. After 30 years’ rapid development, nowdays laparoscopic TME surgery for rectal cancer has become the first choice for those patients with rectal cancer. However, the auxiliary incision of the abdominal wall which is used to remove tumor specimens is contrary to the current concept of minimally invasive surgery. Avoiding abdominal wall incisions has become a common appeal of gastrointestinal surgeons and patients with rectal cancer. Natural orififice specimen extraction surgery (NOSES) can solve the problem of abdominal wall auxiliary incision, which complete rectal cancer radical resection and gastrointestinal reconstruction under the full laparoscopic. The specimens are taken out through the natural orifice (rectum or vagina) without an auxiliary incision, which is more in line with minimally invasive practice and easier to operate. Researching on the progress of laparoscopic radical resection of rectal cancer in NOSES aims to provide a certain reference for this operation.

| 2352344 | ecrin-mdr-crc

Human rectal adenoma (8 cases) vs. rectal carcinoma (8 cases)

Project description:Genomic profiling of human rectal adenoma and carcinoma by array-based comparative genomic hybridization Two group experiment, rectal adenoma vs. rectal carcinoma. Biological replicates: 8 adenomas vs. 8 carcinomas

2011-12-20 | E-GEOD-34472 | biostudies-arrayexpress

RNA-Seq of Tissue, Plasma and Urinary Extracellular Vesicles of Prostate Cancer patients

Project description:We performed RNA-Seq analysis of plasma and urinary EVs collected before and after radical prostatectomy, and matched tumor and normal prostate tissues of 10 patients with prostate cancer. To identify putative cancer-derived RNA biomarkers, we searched for RNAs that were overexpressed in tumor as compared to normal tissues, present in the pre-operation EVs and decreased in the post-operation EVs in each RNA biotype.

2022-11-16 | E-MTAB-11910 | biostudies-arrayexpress

Investigation of continence, sexual- and bowel function after radical surgery for bladder cancer

Project description:Background and study aims Bladder cancer is one of the most common types of cancer worldwide. If the cancer has spread particularly aggressively or keeps coming back after initial treatment, a radical cystectomy may be required. A radical cystectomy is an operation where the entire bladder is removed, as well as nearby organs that may contain cancer cells, such as the prostate and vas deferens (tubes that transport sperm) in men, and the uterus and ovaries in women. Although total removal of the bladder is an effective treatment against the cancer, patients often experience long-term side effects from the surgery. One of the most pronounced after effects are problems with functional problems, namely sexual problems and urinary incontinence. Another common problem following a radical cystectomy is difficulties with bowel movements, such as difficulty passing stools or needing to go urgently. The aim of this study is to look at defecation (rectal function) in patients before and after their radical cystectomy surgery. Who can participate? Adults suffering from bladder cancer, with a planned radical cystectomy. What does the study involve? Before the planned surgery, participants are asked to complete questionnaires regarding their sexual function and continence. Additionally, pressure measurements in the rectum are taken so that rectal function can be determined. Twelve months after the patients have had their radical cystectomy, the questionnaires and function tests are repeated to find out whether the results have changed.

| 2417468 | ecrin-mdr-crc

Fecal microbiota transplant rescues mice from sepsis

Project description:The aim of this study was to test the hypothesis that replenishing the microbiota with a fecal microbiota transplant (FMT) can rescue a host from an advanced stage of sepsis. We developed a clinically-relevant mouse model of lethal polymicrobial gut-derived sepsis in mice using a 4-member pathogen community (Candida albicans, Klebsiella oxytoca, Serratia marcescens, Enterococcus faecalis) isolated from a critically ill patient. In order to mimic pre-operative surgical patient condition mice were exposed to food restriction and antibiotics. Approximately 18 hours prior to surgery food was removed from the cages and the mice were allowed only tap water. Each mouse received an intramuscular Cefoxitin injection 30 minutes prior to the incision at a concentration of 25 mg/kg into the left thigh. Mice were then subjected to a midline laparotomy, 30% hepatectomy of the left lateral lobe of the liver and a direct cecal inoculation of 200 µL of the four pathogen community. On postoperative day one, the mice were administered rectal enema. Mice were given either 1 ml of fecal microbiota transplant (FMT) or an autoclaved control (AC). This was again repeated on postoperative day two. Mice were then followed for mortality. Chow was restored to the cages on postoperative day two, approximately 45 hours after the operation. The injection of fecal microbiota transplant by enema significantly protected mice survival, reversed the composition of gut microflora and down-regulated the host inflammatory response. The cecum, left lobe of the liver, and spleen were isolated from mice for microarray processing with three or more replicates for six expermental conditions: non-treated control, SAHC POD1, SAHC.AC POD2, SAHC.FMT POD2, SAHC.AC POD7, SAHC.FMT POD7

2015-07-30 | E-GEOD-71530 | biostudies-arrayexpress

A multicenter, randomized controlled trial for hand assisted laparoscopic, laparoscopic and robot-assisted radical resection of colorectal cancer

Project description:Interventions: Group 1:hand-assisted laparoscopic radical resection of colorectal cancer;Group 2:laparoscopic-assisted radical resection of colorectal cancer;Group 3:robot-assisted radical resection of colorectal cancer Primary outcome(s): height;weight;Surgical incision length;operation time;Intraoperative blood loss;Number of lymph nodes detected after operation;First exhaust time after surgery;Postoperative hospital stay;Postoperative complication rate;Reoperation rate;Mortality within 30 days after surgery;Intraoperative cost;Local recurrence rate;Disease free survival;Overall survival rate;Postoperative adjuvant chemoradiotherapy rate;First time out of bed after surgery;Time of first postoperative feeding;Time of first urethral catheter extraction after operation;The first time pulling drainage tube after surgery;Tumor staging and typing;Tumor site;Preoperative tumor markers;ASA sizing Study Design: Parallel

| 2683257 | ecrin-mdr-crc

Effect of Ultrasound-Guided erector spinae plane block on postoperative recovery quality of laparoscopic colorectal cancer: a prospective double-blind, randomized control trial

Project description:Interventions: erector spinae plane block group:Ultrasound-guided erector spinae block will be performed before operation;Standard analgesia group:Multimodal analgesia with local incision block after operation Primary outcome(s): 40-item quality of recovery questionnaire;Postoperative Vas (Visual Analogue Scale) scores at rest;postoperative Vas scores at motion Study Design: Parallel

| 47641 | ecrin-mdr-crc